Search results

To fabricate the self‐hardening calcium phosphate composite scaffolds with controlled internal pore architectures using rapid prototyping (RP) techniques and investigate their in vitro bone tissue engineering responses.

The three‐dimensionally interconnected pores in scaffolds can facilitate sufficient supply of blood, oxygen and nutrients for the ingrowth of bone cells, tissue regeneration, and vascularization. It is essential for bone tissue engineering to provide an accurate control over the scaffolds material, porosity, and internal pore architectures. Negative image of scaffold was designed and epoxy resin molds were fabricated on sterolithography apparatus. Calcium phosphate cement slurry was cast in these molds. After self‐hardening, the molds were removed by pyrolysis and the resulting scaffolds were obtained.

Eight scaffolds with 54.45 percent porosity were tested on an Instron machine. The average compressive strength measured was 5.8±0.8 Mpa. Cytotoxicity and cell proliferation studies were conducted with rabbit osteoblast. Results showed that these scaffolds were non‐toxic and displayed excellent cell growth during the 2 weeks of in vitro culture.

The resulting scaffolds inherited errors and defects from the molds, such as cracks and dimensional changes.

The present method enhances the versatility of scaffold fabrication by RP. It is capable of reproducibly fabricating scaffolds from a variety of biomaterials.

This information will be useful in the selection of materials and technology for the detection and removal of mercury ions at a low cost and with high sensitivity and selectivity. The purpose of this study is to provide the useful information for selection of materials and technology to detect and remove the mercury ions from water with high sensitivity and selectivity. The purpose of this study is to provide the useful information for selection of materials and technology to detect and remove the mercury ions from water with high sensitivity and selectivity.

Different nano- and bio-materials allowed for the development of a variety of biosensors – colorimetric, chemiluminescent, electrochemical, whole-cell and aptasensors – are described. The materials used for their development also make it possible to use them in removing heavy metals, which are toxic contaminants, from environmental water samples.

This review focuses on different technologies, tools and materials for mercury (heavy metals) detection and remediation to environmental samples.

This review gives up-to-date and systemic information on modern nanotechnology methods for heavy metal detection. Different recognition molecules and nanomaterials have been discussed for remediation to water samples. The present review may provide valuable information to researchers regarding novel mercury ions detection sensors and encourage them for further research/development.

Porous implant surface is shown to facilitate bone in-growth and cell attachment, improving overall osteointegration, while providing adequate mechanical integrity. Recently, biodegradable material possessing such superior properties has been the focus with an aim of revolutionizing implant’s design, material and performance. This paper aims to present a comprehensive investigation into the design and development of low elastic modulus porous biodegradable Mg-3Si-5HA composite by mechanical alloying and spark plasma sintering (MA-SPS) technique.

This paper presents a comprehensive investigation into the design and development of low elastic modulus porous biodegradable Mg-3Si-5HA composite by MA-SPS technique. As the key alloying elements, HA powders with an appropriate proportion weight 5 and 10 are mixed with the base elemental magnesium (Mg) particles to form the composites of potentially variable porosity and mechanical property. The aim is to investigate the performance of the synthesized composites of Mg-3Si together with HA in terms of mechanical integrity hardness and Young’s moduli corrosion resistance and in-vitro bioactivity.

Mechanical and surface characterization results indicate that alloying of Si leads to the formation of fine Mg2 Si eutectic dense structure, hence increasing hardness while reducing the ductility of the composite. On the other hand, the allying of HA in Mg-3Si matrix leads to the formation of structural porosity (5-13 per cent), thus resulting in low Young’s moduli. It is hypothesized that biocompatible phases formed within the composite enhanced the corrosion performance and bio-mechanical integrity of the composite. The degradation rate of Mg-3Si composite was reduced from 2.05 mm/year to 1.19 mm/year by the alloying of HA elements. Moreover, the fabricated composites showed an excellent bioactivity and offered a channel/interface to MG-63 cells for attachment, proliferation and differentiation.

Overall, the findings suggest that the Mg-3Si-HA composite fabricated by MA and plasma sintering may be considered as a potential biodegradable material for orthopedic application.

To relieve intracranial pressure and save patient inflicted with severe head injury, neurosurgeons restore cranial defects. These defects can be caused because of trauma or diseases (Osteomyelitis of bone) which are treated by cranioplasty, using the preserved bone of patient. In case of non-availability of bone, a cranial implant is generated using a biocompatible synthetic material, but this process is less accurate and time-consuming. Hence, this paper aims to present the use of rapid prototyping technology that allows the development of a more accurate patient-specific template and saves the surgery time.

A five-year-old girl patient having cranial defect was taken up for cranioplasty. CT (computed tomography) scans of the patient were used to generate 3D design of the implant suitable to conceal the defect on the left frontal portion using CAD/CAM (computer-aided design/ computer-aided manufacturing) software. The design was used for 3D printing to manufacture a base template, which was finally used to fabricate the actual implant using Simplex® P bone cement material to conceal the defect.

Surgery using Simplex® P implant was performed successfully on the patient, giving precise natural curvature to left frontal portion of the patient, decreasing surgery time by about 30 per cent.

The case demonstrates the development of a convenient, time-saving and aesthetically superior digital procedure to treat cranial defect in the absence of preserved bone flap using CT scan as input. 3D modelling and printing were deployed to produce an accurate template which was used to generate an implant using bone cement biocompatible material.

This study aims to optimize the process parameters of ZPrinter® 450 for measured porosity (MP) and compressive strength (CS) of calcium sulfate-based porous bone scaffold using Taguchi approach.

Initially, a porous scaffold with smallest pore size that can be de-powdered completely is identified through a pilot study. Five printing parameters, namely, layer thickness (LT), build orientation (BO), build position (BP), delay time (DT) and binder saturation (BS), each at three levels have been optimized for MP and CS of the fabricated scaffolds using L27 orthogonal array (OA), signal-to-noise ratio and analysis of variance (ANOVA).

The scaffolds with 600 µm pores could be de-powdered completely. Optimum levels of parameters are LT₂, BO₁, BP₂, DT₁ and BS₁ for MP and LT₁, BO₁, BP₂, DT₁ and BS₂ for CS. The ANOVA reveals that the BS (49.12%) is the most and BP (8.34%) is the least significant parameter for MP. LT (50.84%) is the most, BO (33.79%) is second most and DT (2.59%) is the least significant parameter for CS. Taguchi confirmation test and linear regression models indicate a good agreement between predicted and experimental values of MP and CS. The experimental values of MP and CS at the optimum levels of parameters are found 38.12% and 1.29 MPa, respectively.

The paper presents effect of process parameters of ZPrinter® 450 on MP and CS of calcium sulfate-based porous scaffolds. Results may be used as guideline for powder bed binder jetting three-dimensional printing of ceramic scaffolds.

The purpose of this paper is establishing a general mathematical model and theoretical design rules for 3D printing of biomaterials. Additive manufacturing of biomaterials provides many opportunities for fabrication of complex tissue structures, which are difficult to fabricate by traditional manufacturing methods. Related problems and research tasks are raised by the study on biomaterials’ 3D printing. Most researchers are interested in the materials studies; however, the corresponded additive manufacturing machine is facing some technical problems in printing user-prepared biomaterials. New biomaterials have uncertainty in physical properties, such as viscosity and surface tension coefficient. Therefore, the 3D printing process requires lots of trials to achieve proper printing parameters, such as printing layer thickness, maximum printing line distance and printing nozzle’s feeding speed; otherwise, the desired computer-aided design (CAD) file will not be printed successfully in 3D printing.

Most additive manufacturing machine for user-prepared bio-material use pneumatic valve dispensers or extruder as printing nozzle, because the air pressure activated valve can print many different materials, which have a wide range of viscosity. We studied the structure inside the pneumatic valve dispenser in our 3D heterogeneous printing machine, and established mathematical models for 3D printing CAD structure and fluid behaviors inside the dispenser during printing process.

Based on theoretical modeling, we found that the bio-material’s viscosity, surface tension coefficient and pneumatic valve dispenser’s dispensing step time will affect the final structure directly. We verified our mathematical model by printing of two kinds of self-prepared biomaterials, and the results supported our modeling and theoretical calculation.

For a certain kinds of biomaterials, the mathematical model and design rules will have unique solutions to the functions and equations. Therefore, each biomaterial’s physical data should be collected and input to the model for specified solutions. However, for each user-made 3D printing machine, the core programming code can be modified to adjust the parameters, which follows our mathematical model and the related CAD design rules.

This study will provide a universal mathematical method to set up design rules for new user-prepared biomaterials in 3D printing of a CAD structure.

This paper aims to introduce selective vacuum manufacturing (SVM), a powder-based rapid prototyping (RP) technique, and the ongoing development to improve its capability to apply in temporary scaffold fabrication.

SVM employs a combination of sand casting and powder sintering process to construct a prototype layer by layer. A dense layer of support material is prepared and selectively removed to create a cavity where part material is filled and sintered to form a solid layer. In order for SVM to be considered for scaffold fabrication, besides preparing poly-lactic acid (PLA) for part material, support material preparation and process parameters identification have been studied. Redesigning of SVM machine to be more suitable for the real usage has also been presented.

Particle size of salt has been controlled, and its suitable composition with flour and water has been determined. Process parameters have been identified to scale down the size of scaffolds to meso-scale and to achieve mechanical requirement. Properties of fabricated scaffolds have been enhanced and can be used for soft tissue applications. A prototype of the medical SVM machine has been constructed and tested. An examination of scaffolds fabricated on this new machine also showed their qualification for soft tissue application.

Further study will be on conducting a direct cytotoxicity test to provide the evidence for tissue growth before the clinical usage, on continuing to scaling down the scaffold size, and on improving SVM to meet the requirement of hard tissue.

This simple, inexpensive RP technique demonstrates its viability for scaffold fabrication.

Fused deposition modelling (FDM) is the most economical additive manufacturing technique. The purpose of this paper is to describe a detailed review of this technique. Total 211 research papers published during the past 26 years, that is, from the year 1994 to 2019 are critically reviewed. Based on the literature review, research gaps are identified and the scope for future work is discussed.

Literature review in the domain of FDM is categorized into five sections – (i) process parameter optimization, (ii) environmental factors affecting the quality of printed parts, (iii) post-production finishing techniques to improve quality of parts, (iv) numerical simulation of process and (iv) recent advances in FDM. Summary of major research work in FDM is presented in tabular form.

Based on literature review, research gaps are identified and scope of future work in FDM along with roadmap is discussed.

In the present paper, literature related to chemical, electric and magnetic properties of FDM parts made up of various filament feedstock materials is not reviewed.

This is a comprehensive literature review in the domain of FDM focused on identifying the direction for future work to enhance the acceptability of FDM printed parts in industries.

This study aims to explore the enhancement of mechanical properties in epoxy resin composites through the incorporation of graphene nanoparticles, focusing on their impact and wear resistance. It investigates the role of graphene, both treated and untreated, as a reinforcing agent in composites, highlighting the significance of nanoparticle dispersion and surfactant treatment in optimizing mechanical performance.

Employing a novel dispersion technique using a drawing brush, this research contrasts with traditional methods by examining the effects of graphene nanoparticle concentrations treated with surfactants – Polyvinylpyrrolidone (PVP) and Sulphonated Naphthalene Formaldehyde (SNF) – on the mechanical properties of epoxy resin composites. The methodology includes conducting a series of impact and wear tests to assess the influence of graphene reinforcement on the composites' performance.

The findings reveal a marked enhancement in the composites impact resistance and energy absorption capabilities, which escalate with an increase in graphene content. Additionally, the study demonstrates a significant improvement in wear resistance, attributed to the superior mechanical properties, robust interface adhesion and effective dispersion of graphene. The use of surfactants for graphene treatment is identified as a crucial factor in these advancements, offering profound insights into the development of advanced composite materials for diverse industrial uses.

This study introduces a unique dispersion technique for graphene in epoxy composites, setting it apart from conventional methods. By focusing on the critical role of surfactant treatment in enhancing the mechanical properties of graphene-reinforced composites, it provides a novel insight into the optimization of impact and wear resistance.