Association between dietary inflammatory index and kidney function in elderly population: Results from a cross-sectional study
ISSN: 0034-6659
Article publication date: 12 December 2018
Issue publication date: 9 May 2019
Abstract
Purpose
This study aims to investigate the association of the dietary inflammatory index (DII), kidney function and high-sensitivity C-reactive protein (hs-CRP) among the senior population (60-83 years).
Design/methodology/approach
This cross-sectional study was conducted in 221 elderly subjects who are living in Tehran, Iran. The DII was calculated from validated semi-quantified food frequency questionnaire, combining putatively pro-inflammatory and anti-inflammatory effects of nutrients, vitamins and trace elements. Biochemical measurements of blood and urine samples were measured. The estimated glomerular filtration rate (eGFR) was assessed from serum creatinine.
Findings
A total of 221 subjects with mean BMI of 29.75 and age ranged 60-83 years old were included in the current study. Multiple linear regression analysis showed that eGFR (ß = –0.471; p = 0.48; 95 per cent CI: –2.90, 2.63), albumin/creatinine ratio (ACR) (ß = 0.041 p = 0.55; 95 per cent CI: –5.12, 9.46) and hs-CRP (ß = 0.004; p = 0.55; 95 per cent CI: –0.96, 1.79) were not associated with the DII before and after adjusting for potential confounders, including energy intake, age, sex, BMI, smoking status, physical activity, hypertension, diabetes, use of lipid-lowering medication, angiotensin II receptor blockers (ARB) and angiotensin-converting enzyme inhibitor (ACEI), steroidal and non- steroidal anti-inflammatory medications.
Research limitations/implications
Due to the cross-sectional nature of this study, it is difficult to find the cause-and-effect relationship between the DII and the serum hs-CRP concentration. Another limitation of our study is concerning a possible overestimation or underestimation of dietary intakes, because the participants in the study were elderly and FFQ is a memory-based questionnaire.
Originality/value
Our findings suggest that the DII score is not associated with serum hs-CRP and kidney function markers in elderly people.
Keywords
Acknowledgements
The authors acknowledge Tehran University of Medical Sciences for the financial support (grant number: 29544) for the study additionally.
Author contributions: Sakineh Shabbidar (SS-b) designed and supervised the study, was involved in laboratory analyses and wrote the finalized manuscript. Somayeh Tajik (ST) both helped intellectually in finalizing the study design. ST performed most of the laboratory analyses. ST and Saragol Eimery (SE) wrote the preliminary manuscript and were actively involved in the field work. This study was part of her MSc thesis at the TUMS under the supervision of SS-b (grant number: 29544). All statistical analyses were done under the supervision of Abbas Rahimi-Foroushani (ARB). Sara Mansouri (SM) together with SE performed laboratory analyses.
Citation
Tajik, S., Eimeri, S., Mansouri, S., Rahimi-Foroushani, A. and Shab-Bidar, S. (2019), "Association between dietary inflammatory index and kidney function in elderly population: Results from a cross-sectional study", Nutrition & Food Science, Vol. 49 No. 3, pp. 491-503. https://doi.org/10.1108/NFS-07-2018-0197
Publisher
:Emerald Publishing Limited
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