A dose-response and meta-analysis of phytosterols consumption on liver enzymes: Evidence from randomized clinical trials
ISSN: 0034-6659
Article publication date: 24 September 2019
Issue publication date: 22 April 2020
Abstract
Purpose
The results of human studies evaluating the efficacy of plant Phytosterols on liver function were inconsistent. Therefore, the purpose of this paper is to eliminate these controversies about the Phytosterols consumption on liver serum biochemistry in adult subjects.
Design/methodology/approach
The literatures systematically searched throughout PubMed and Scopus databases up to June 2018; it was conducted by using related keywords. Estimates of effect sizes were expressed based on weighted mean difference (WMD) and 95% CI from the random-effects model (erSimonian and Laird method). Heterogeneity across studies was assessed by using I2 index. Eighteen studies reported the effects of Phytosterols (PS) supplementation on liver serum biochemistry.
Findings
The current meta-analysis did not show a significant effect on ALT (MD: 0.165 U/L, 95% CI: −1.25, 1.58, p = 0.820), AST (MD: −0.375 IU/Liter, 95% CI: −1.362, 0.612, p = 0.457), ALP (MD: 0.804 cm, 95% CI: −1.757, 3.366, p = 0.538), GGT (MD: 0.431 U/L, 95% CI: −1.803, 2.665, p = 0.706) and LDH (MD: 0.619 U/L, 95% CI: −4.040, 5.277, p = 0.795) following PS consumption.
Originality/value
The authors found that no protective or toxic effects occur after the consumption of Phytosterols on liver enzymes including ALT, AST, ALP, LDH and GGT.
Keywords
Acknowledgements
The authors sincerely thank Shahid Beheshti University of Medical Sciences for all moral and material supports. This study was supported by grants from the Student Research Committee, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran (Grant’s ID: 1397/69264).
Conflict of interest: There was no competing financial interest in relation to current study.
Authors’ contributions to manuscript: HK_V and ST designed and conducted the research; JR and SMM screened and extracted articles information; HK_V and SMM performed statistical analysis; ASS and KJ wrote the paper; HK_V and AK had primary responsibility for final content. All authors read and approved the final manuscript.
Citation
Tajik, S., Jacobson, K., Talaei, S., Kord-Varkaneh, H., Noormohammadi, Z., Salehi-Sahlabadi, A., Pezeshki, M., Rahmani, J. and Hekmatdoost, A. (2020), "A dose-response and meta-analysis of phytosterols consumption on liver enzymes: Evidence from randomized clinical trials", Nutrition & Food Science, Vol. 50 No. 3, pp. 579-600. https://doi.org/10.1108/NFS-06-2019-0182
Publisher
:Emerald Publishing Limited
Copyright © 2019, Emerald Publishing Limited