Does combination of Lactobacillus rhamnosus Heriz I and beta glucan improve quality of life in women with breast cancer receiving chemotherapy? A randomized double-blind placebo-controlled clinical trial
ISSN: 0034-6659
Article publication date: 24 September 2019
Issue publication date: 22 April 2020
Abstract
Purpose
This paper aims to study the impact of combination Lactobacillus Rhamnosus Heriz I and Beta glucan on quality of life (QOL) in breast cancer (BC) patients receiving chemotherapy.
Design/methodology/approach
In all, 30 women with BC were enrolled in this randomized double-blind placebo-controlled clinical trial. Intervention group received either daily one capsule of L. rhamnosus strain Heriz I (2 × 107 CFU) and two 10-mg capsules of soluble1–3,1–6,D-beta glucan and the placebo group receiving placebo, interval between two courses of chemotherapy. Health-related QOL was evaluated at baseline and end of the trial using the EORTC QOL Questionnaire version.3.0 (EORTC QLQ-C30).
Findings
The results showed that combination of L. rhamnosus Heriz I and Beta glucan supplementation in BC patients during chemotherapy improved functional scales score from 37.3 ± 12.1 to 39.8 ± 6.8 and this increase in comparison with placebo was significant after adjusting baseline value (p = 0.015). Changes in symptoms scores were not significant after intervention (p = 0.05) but the decreased score (66.1 ± 12.9 to 60.6 ± 9.4) was considerable clinically. As well as, changes in global health status/QOL score in intervention group in comparison with the placebo group was not significant (p = 0.93).
Originality/value
The findings suggest that combination of L. rhamnosus Heriz I and Beta glucan may be associated for improving functional scales and symptoms in patients with BC who underwent chemotherapy. To prove positive effect of supplements on other aspects of QOL, further studies are needed.
Keywords
Acknowledgements
The authors acknowledge all the women who participated in this study. The present study was funded by Hematology Oncology Research Center of Tabriz University of Medical Sciences. The authors thank Quality of Life department in EORTC for authorizing the EORTC QLQ-C30 questionnaire use in this study. This article is from a data set of PhD thesis, registered in Tabriz University of Medical Sciences (No.d/31).
The authors have no conflict of interest.
Citation
Monshikarimi, A., Ostadrahimi, A., Asghari Jafarabadi, M., EivaziZiaei, J., Barzeghari, A., Esfahani, A., Payahoo, L., Aamazadeh, F. and Farrin, N. (2020), "Does combination of
Publisher
:Emerald Publishing Limited
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