Synthesis of annulated and substituted pyrido[2,3‐d] pyrimidines as antimicrobial agents

Abstract

Various routes to the synthesis of annulated and substituted pyrido[2,3‐d]pyrimidines are reported. In particular, the reactions of N‐{3‐cyano‐6‐[4(5‐oxo‐2‐ phenylhydrazono‐4,5‐dihydroimid‐azol‐1‐yl)phenyl]‐4‐ phenylpyridin‐2‐yl}formimidic ethyl ester (3) and 3‐[4‐(3‐amino‐4‐imino‐5‐phenyl‐3,4‐dihydropyrido [2,3‐d]pyrimidin‐7‐yl)phenyl]‐2‐phenyl‐5‐phenyl‐ hydrazono‐3,5‐dihydroimidazol‐4‐one (4) with a variety of reagents were investigated. The antimicrobial activity of some of the compounds obtained were evaluated and reported.

Citation

Issac, Y.A. (2003), "Synthesis of annulated and substituted pyrido[2,3‐d] pyrimidines as antimicrobial agents", Pigment & Resin Technology, Vol. 32 No. 6, pp. 371-381. https://doi.org/10.1108/03699420310507821