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The aim of this paper is to provide insight into how to deal with safety issues during construction projects at multi‐functional urban locations.

A case study comprising several construction projects for high‐rise buildings over a motorway in The Hague provided insight into the complexity of the safety management. A process model was designed of moments of influence of safety measures. This was combined with quantitative risk analyses of some alternative safety measures using failure mode and effect analysis and Bayesian networks.

It is essential to put safety management on the agenda at a very early stage in the planning process for construction projects at multi‐functional urban locations. The erection of heavy structural elements when building activities are being carried out above a motorway is an important risk factor. Structural measures appear to be more cost‐effective than closing off the road.

The methods used to develop insight into the cost‐effectiveness of different safety measures can also be applied to construction processes at multi‐functional urban locations. This might lead to different conclusions on which measures are preferable.

There is very little literature or general knowledge on how to deal with these safety issues. This paper provides a method that can be applied in the development of safety protocols at multi‐functional urban locations.