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The purpose of this paper is to compare the stability of the three nanocarriers created by DNA origami method with different positions and numbers of crossovers

Nanocarriers are attractive components among a variety of nanostructures created by DNA origami and can have numerous applications in mechanical and medical engineering. For this reason, the current study compares three nanotubes with different positions and numbers of crossovers created by DNA origami method that can be utilized as nanocarriers. To investigate the structures, the DNA nanocarriers are studied at the human body temperature 310 K. Molecular dynamics simulations are used for this study. For a quantitative analysis of DNA nanocarriers, the areas of three hexagons at three different sites in each of the nanotubes are investigated. The results indicate that the number and position of crossovers are among the significant factors in the structure stability of nanocarriers. The analyses also revealed that although adding crossovers in locations with fewer crossovers increase structural stability, the position of crossovers can have different effects on the stability. DNA origami-based nanocarriers can be implemented in drug delivery, allow the nanocargoes to pass various surfaces and act as filters for passing cargoes of different dimensions and chemical structures.

The results indicate that the number and position of crossovers are among the significant factors in the structure stability of nanocarriers

In this paper, the stability of DNA origami nanocarriers with different positions and numbers of crossovers was investigated.

The present study aims to design and simulate various types of deoxyribonucleic acid (DNA) origami-based nanopores and explore their stability under different temperatures and constraints. To create DNA origami nanopores, both one-layer and two-layer structures can be utilized.

One of the key applications of DNA origami structures involves the creation of nanopores, which have garnered significant interest for their diverse applications across multiple scientific disciplines. DNA origami nanopores can be studied individually and in combination with other structures. The structural stability of these nanopores across various temperature conditions is crucial for enabling the passage of diverse payloads.

Comparing these DNA origami structures can provide valuable insights into the performance of these nanopores under different conditions. The results indicate that two-layer nanopores exhibit better structural stability under various temperatures compared to one-layer nanopores. Additionally, small structural changes in two-layer nanopores enable them to maintain stability even at high temperatures.

In this paper, various DNA origami-based nanopores were designed and simulated, focusing specifically on one-layer and two-layer configurations. The two-layer nanopore consistently exhibited superior stability across both free and restrained scenarios, undergoing fewer structural changes compared to the one-layer nanopore. As temperatures increased, the two-layer nanopore remained less susceptible to deformation, maintaining closer to its original shape. Moreover, in the free scenario, the geometric shape of the two-layer nanopore demonstrated fewer variations than the one-layer nanopore.