Majid Monajjemi and Fatemeh Mollaamin
Early prediction of any type of cancer is important for the treatment of this type of disease, therefore, our target to evaluate whether monitoring early changes in plasma human…
Abstract
Purpose
Early prediction of any type of cancer is important for the treatment of this type of disease, therefore, our target to evaluate whether monitoring early changes in plasma human epidermal growth factor receptor 2 (HER2) levels (using EIS), could help in the treatment of breast cancer or not? Human epidermal growth factor receptor 2 (HER2) overexpression is an important biomarker for treatment selection in earlier stages of cancers. The combined detection of the HER2 gene in plasma for blood cancer provides an important reference index for the prognosis of metastasis to other tissues. For this purpose, the authors fabricated and characterized a model wireless biosensor-based electrochemical impedance spectroscopy (EIS) for detecting HER2 plasma as therapeutics.
Design/methodology/approach
Most sensors generally are fabricated based on a connection between component of the sensors and the external circuits through wires. Although these types of sensors provide suitable sensitivities and also quick responses, the connection wires can be limited to the sensing ability in various devices approximately. Therefore, the authors designed a wireless sensor, which can provide the advantages of in vivo sensing and also long-distance sensing, quickly.
Findings
The biosensor structure was designed for detection of HER2, HER3 and HER-4 from lab-on-chip approach with six units of screen-printed electrode (SPE), which is built of an electrochemical device of gold/silver, silver/silver or carbon electrodes. The results exhibited that the biosensor is completely selective at low concentrations of the plasma and HER2 detection via the standard addition approach has a linearity plot, therefore, by using this type of biosensors HER2 in plasma can be detected.
Originality/value
This is then followed by detecting HER2 in real plasma using standard way which proved to have great linearity (R2 = 0.991) proving that this technique can be used to detect HER2 solution in real patients.
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Bhumika Ray, Atri Sengupta and Arup Varma
Despite the popularity of gig employment amid the changing business landscape, gig scholarship is somewhat limited and the untold reality about gig is yet to be fully revealed…
Abstract
Purpose
Despite the popularity of gig employment amid the changing business landscape, gig scholarship is somewhat limited and the untold reality about gig is yet to be fully revealed. This study aims to critically address the nature of gig employment, its ambiguities, evolution, theoretical premises and the appropriate future road ahead.
Design/methodology/approach
This paper adopts a dual analytical approach – bibliometric and thematic analyses. After incorporating the exclusion–inclusion criteria, the authors identified 2,135 articles for the bibliometric analyses by using VOSviewer. Additionally, for the deep-delving synthesis, the authors conducted thematic analyses following Braun and Clarke (2006), based on 351 papers.
Findings
The findings revealed that gig work, in its different forms, is emerging as an alternative work arrangement with respect to the future of work. This study also identified multilevel perspectives of gig employment along with its holistic nomological network. Finally, this study offers some critical research directions that should help enhance the theoretical and practical strengths of this nascent scholarship in future.
Research limitations/implications
The review findings are limited in nature owing to the paucity of quality research papers published in the said domain.
Practical implications
The paper brings more clarity to what gig is and isn’t, along with its critical perspectives from multilevel lenses.
Originality/value
This paper identifies critical perspectives related to gig work and suggests appropriate directions for future gig work related scholarship.
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Aya Diab and Danielle L. Johnson
Children in armed conflict sites exist as a representative of the beginning of life in a space that serves as a constant reminder of the end of life. When children die in these…
Abstract
Children in armed conflict sites exist as a representative of the beginning of life in a space that serves as a constant reminder of the end of life. When children die in these spaces, they become representatives of the pervasive death that looms in and around armed conflict sites. Narrating children through online memorials is one way in which to breathe life back into these children and highlight the atrocities in armed conflict spaces. Looking specifically at the Syrian Civil War, this piece examined English language memorials for children who have died in the Syrian Civil War to understand narrative similarities and differences. The authors first hypothesized that regardless of the post, children were regarded with positive language, as established by previous child memorial research. Second, we hypothesized that there could be some noticeable differences in who’s to blame for the children’s death in two main ways: blaming the regime of Bashar Al-Assad or the Armed Syrian Opposition. Despite focusing on memorials about children, children were missing from the memorials (Theme A: Where Are the Children?). Ever present in the memorials was the conflict between Bashar Al-Assad and the Armed Syrian Opposition (Theme B: Blame Game: Bashar Al-Assad and the Armed Syrian Opposition). This chapter expanded the research areas of online narratives, children in armed conflict sites, and the end-of-life topic area.
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William Hendradjaja and Moon Leoma
Social entrepreneurs want to help solve social and environmental issues by applying entrepreneurial solutions. However, social entrepreneurs usually find it more challenging to…
Abstract
Social entrepreneurs want to help solve social and environmental issues by applying entrepreneurial solutions. However, social entrepreneurs usually find it more challenging to measure their success because of the metric that is being measured is not only for financial gain but also for social and environmental change. The analysis of how they manage and achieve their impact goals, which are restricted by limited knowledge and resources, is unfortunately not always the highest priority particularly in the early stage of their entrepreneurial journey.
Frequently, by generating social and economic value, business decisions and actions are in opposition (Dawan & Alter, 2009). This opposition translates into calculated trade-offs. At times decisions may be adequate that forsake social impact in order to gain market share or increase profit margins and increase social value creation in the long run. Conversely, the scope of social impact may be expanded at a financial cost (Braun, 2020).
What also often happens in our experience is that more social businesses claim their impact without clear justification based on measurement. And even worse is that many social entrepreneurs are not equipped with the right mindset and tools to understand how to measure, manage and maximise their impact.
Also, the situation with COVID-19 pandemic makes it even more pressing now that businesses must be held accountable for their actions; decisions solely relying on financial gain are even less relevant during this time. The pandemic will likely create even more inequality, with evidence emerging that those at the bottom of pyramid are being more severely affected. Casualties will be even more with the virus spreading faster on the bottom-of-the-pyramid communities, and we have seen that hospitals and proper medical care are being allocated improperly with several privilege for some people with more resources. The implication of these inequalities will have a profound impact on every level and aspect of communities.
Here in this chapter, we will discuss the challenges through our experiences in practicing impact management and why it's very important to be done at all levels of the entrepreneurial stage even from the upstart and what can be done better to help social and all entrepreneurs to strive.
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Ree Jordan, Terrance W. Fitzsimmons and Victor J. Callan
Workplace mavericks are often labeled as non-conformists. They are perceived to be the employees who disregard organizational policies and procedures, and who invite huge risks in…
Abstract
Workplace mavericks are often labeled as non-conformists. They are perceived to be the employees who disregard organizational policies and procedures, and who invite huge risks in the pursuit of goals that sit outside what the organization dictates as the core business or practice. While this may be accurate to a degree, it is not the complete story. Guided by recent conceptualizations of non-conformity and positive deviance, this qualitative study interviewed 27 observers of mavericks (observer-types) in the workplace, and 28 interviews with mavericks (maverick-types). Results highlight that while maverick individuals do challenge organizational norms, they do so for the benefit of others, including the organization. Additionally, they are not wildcard non-conformists as they do in fact conform. However, they are conforming positively to higher level hyper-norms or organizational goals, and therefore operate in what could be termed as bounded non-conformity. Understanding the form that this bounded non-conformity takes is key for organizations to mitigate perceptions of the risk posed by maverick individuals, while maximizing the rewards that maverick employees can offer to organizations, especially for informing ideas and plans around more radical change and innovation. In this way, organizations can benefit from the numerous and unique contributions of mavericks in the workplace, such as innovative, unorthodox, and out-of-the-box thinking, while at the same time still ensuring the effective governance and risk management of the organization.
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Katarzyna Bachnik, Liza Howe-Walsh, Lisa Critchley, Marisa Alicea, Maria Guajardo and Christa Ellen Washington
This study aims to explore the individual lived crucible experiences of women leaders in higher education (HE) and business as the catalyst to investigate organisational…
Abstract
Purpose
This study aims to explore the individual lived crucible experiences of women leaders in higher education (HE) and business as the catalyst to investigate organisational inequality regimes that prevent women leaders from fully participating, contributing and flourishing at work. Drawing upon Bolman and Deal’s four-frame theoretical organisational model, this study analyses women’s lived crucible leadership experiences to better understand the organising processes and practices that render intersectionality invisible that reinforce and perpetuate inequality regimes.
Design/methodology/approach
A collaborative autoethnographic research method was selected for data collection. The research team members each selected one significant crucible moment from their professional career and used the Gibb’s six-part reflective cycle to document their narrative and reflect on their leadership experience. A reflexive thematic analysis was used based on Braun and Clarke’s six phases.
Findings
The study features the importance of creating a climate in organisations that acknowledges the need for greater equity, diversity and inclusion (EDI) to support women leaders. Four global themes emerged from the analysis of the leadership narratives: organisation, power dynamics, emotional distress and perseverance and intersectionality. These themes illuminate a greater understanding of organisational life for women and confirm the presence of inequality regimes of gender and race.
Originality/value
This is the first study to explore the impact of women leaders’ crucible experiences through the lens of the Bolman and Deal’s model that highlights the need to consider an EDI lens as the fifth frame.
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Marek Szelągowski, Piotr Biernacki, Justyna Berniak-Woźny and Cezary Radosław Lipinski
The aim of the article is to propose BPMN extensions that facilitate the modeling of Clinical Pathways in a way that enables for various groups of users, the transfer of a much…
Abstract
Purpose
The aim of the article is to propose BPMN extensions that facilitate the modeling of Clinical Pathways in a way that enables for various groups of users, the transfer of a much wider range of information in the form of process models without compromising their readability and usefulness.
Design/methodology/approach
The paper uses the design science research methodology (DSRM) and covers phases of a design-oriented research project extending BPMN notation for clinical pathway modeling.
Findings
The article proposes extensions of BPMN in 5 areas, enabling standardization of the description of business processes of different natures and complexity and in turn meeting the needs and requirements of modeling clinical pathways and, more broadly speaking, knowledge-intensive business processes (kiBPs) in general. As shown by the evaluation carried out among medical personnel, the proposed extensions allow for the readable transfer of a considerably larger body of information relevant to the planned, conducted and assessed therapy (kiBPs) than the current BPMN 2.0 standard.
Originality/value
The BPMN extensions proposed in the article fill the gaps in this notation and do not require users to know many notations, which in practice is unrealistic. Defined extensions to the BPMN specification makes it possible to standardise the description of processes of different natures and levels of complexity. In this way, both simplified models (and views of models) dedicated to users unfamiliar with BPMN and models (or views) using advanced possibilities provided by BPMN can be based on one standard, even if they use only a small part of its possibilities.
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Damian Charles Hine, Helge Helmersson and Jan Mattsson
The purpose of this paper is to focus on the need in biotechnology to integrate a variety of knowledge bases to build the intellectual asset base of the commercial entity…
Abstract
Purpose
The purpose of this paper is to focus on the need in biotechnology to integrate a variety of knowledge bases to build the intellectual asset base of the commercial entity operating in the biotechnology industry.
Design/methodology/approach
The paper is based upon a single case study of a young biotechnology company, itself relying on the knowledge and expertise of four directors. To analyze the responses of the four directors to a single lead question, designed to prompt the respondents to articulate the intellectual capital they offer to the firm, this study employs a novel text analytical tool known as Perspective Text Analysis (Pertex).
Research limitations/implications
The results show the disparate nature of the individual knowledge sets in contributing to the interdisciplinary base of the firm. The combined analysis illustrates the importance of collective intellectual capital through “sustainable collaboration.”
Originality/value
This study employs a novel analytical tool to undertake an analysis of both individual intellectual capital and collective interdisciplinary contribution using data from a single question. Pertex is a valuable tool in analyzing the intentionality of a respondent by cutting through to the true essence of their response.