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Based on DNase I and reduced graphene oxide (rGO)-magnetic silicon microspheres (MNPS), a highly sensitive and selective fluorescent probe for the detection of PD-L1 was developed.

Here °C we present a feasibility of biosensor to detection of PD-L1 in lung tumors plasma. In the absence of PD-L1°C the PD-L1 aptamer is absorbed on the surface of graphene oxide modified magnetic nanoparticles °8rGO-MNPS°9 and leading to effective fluorescence quenching. Upon adding PD-L1°C the aptamer sequences could be specifically recognized by PD-L1 and the aptamer/PD-L1 complex is formed°C resulting in the recovery of quenched fluorescence.

This sensor can detect PD-L1 with a linear range from 100 pg mL⁻¹ to 100 ng mL⁻¹, and a detection limit of 10 pg•m⁻¹ was achieved.

This method provides an easy and sensitive method for the detection of PD-L1 and will be beneficial to the early diagnosis and prognosis of tumors.

After the official definition of Open Educational Resources (OER) at the Forum on Open Courseware for Higher Education in Developing Countries in 2002, the concept was soon introduced to China and popularised among scholars, practitioners, and educators. After ten years of proliferation, it is important to explore the landscape of Chinese OER research. The paper aims to discuss these issues.

This paper adopts social network analysis (SNA) to analyse the network defining the citations of 133 OER journal articles published in China.

The findings illustrate that the academic circle of OER in China is small, which leads to restricted innovation. Most publications are produced by researchers working at comprehensive universities and normal universities (teachers colleges).

In these universities, a number of active OER researchers are emerging, but no OER research team can be identified from their citation networks. Currently, most OER research is still descriptive research, and only few case studies are being to gradually be conducted.

As the Chinese OER research is still in the initial stage, more research projects in OER need to be explored to construct higher quality and more influential open content to achieve deep openness.

In the literature, no one has adopted the SNA to analyse the citation network of Chinese OER research.

The purpose of this paper is to further explore the co-citation and bibliographic-coupling relationship among the core authors in the field of Chinese information science (IS), to expose research activity and author impact, and to make induction analyses about Chinese IS research patterns and theme evolution.

The research data include 8,567 papers and 70,947 cited articles in the IS field indexed by Chinese Social Sciences Citation Index from 2000 to 2009. Author co-citation analysis, author bibliographic-coupling analysis, social network analysis, and factor analysis were combined to explore co-citation and bibliographic-coupling relationships and to identify research groups and subjects.

Scholars with greatest impact are different from the most active scholars of Chinese IS; there is no uniform impact pattern forming since authors’ impact subjects are scattered and not steady; while authors’ research activities present higher independence and concentration, there is still no steady research pattern due to no deep research existing. Furthermore, Chinese IS studies can be delineated by: foundation or extension. The research subjects of these two parts, as well as their corresponding/contributing authors, are different under different views. The general research status of core authors is concentrated, while their impact is broad.

The combined use of some related methods could enrich the development and methodology research of the discipline, and the results establish a reference point on the development of IS research.