Sukumar Nachiappan, Lami Amanuel, Tewodros Agazie and Seyoum Bihonegn
Wound healing is a dynamic process that relies on coordinated signaling molecules to succeed. Silk has proven to be a promising biomaterial for the development of a novel product…
Abstract
Purpose
Wound healing is a dynamic process that relies on coordinated signaling molecules to succeed. Silk has proven to be a promising biomaterial for the development of a novel product. The purpose of the study is development of silk films, augmented functionality can be provided to silk by means of loading honey and recombinant human epidermal growth factor (rhEGF).
Design/methodology/approach
In this research work, the authors set out to explore possibilities of silk-based biomedical device development with particular attention to different fabrication strategies that can be leveraged for this purpose. They have produced a novel silk-based drug delivery material, in the form of silk films. Scanning electronic microscope was used to observe the morphology and the highly specific surface area. The structure was studied by Fourier-transform infrared spectroscopy. This methodology is accomplished using in vivo study data using Wister albonia rats.
Findings
The developed films also provided a significant higher healing rate in vivo, with well-formed epidermis with faster granulation tissue formation when compared to the controls. Biodegradable polymeric materials based on blending aqueous dispersions of natural polymer sodium alginate, Chitosan and rhEGF complex, which allow controlled antiseptic release, are presented.
Originality/value
These results suggest that silk-based controlled release of Chitosan-rhEGF may serve as a new therapy to accelerate healing of burn wounds.
Details
Keywords
Nachiappan Sukumar, Mekonnen Bayeleyegn and Sampath Aruna
Recently, composites have concerned considerable importance as a potential operational material. Lots of work have been carried out to enhance the mechanical properties of…
Abstract
Purpose
Recently, composites have concerned considerable importance as a potential operational material. Lots of work have been carried out to enhance the mechanical properties of composites. The main aim of this paper is to develop bamboo mat as reinforcing material with bagasse fiber as filler using epoxy resin matrix composite.
Design/methodology/approach
In this research, the effect of fiber surface treatments on mechanical properties of epoxy resin composite with bagasse as filler has been developed and investigated. The extracted bamboo fibers were treated with NaOH to improve the surface roughness fiber. Using treated and untreated bamboo fiber handwoven mat has been produced to be used as reinforcement and bagasse fiber has been converted into powder to be filled as filler. Composite material is fabricated using bamboo fiber and bagasse fiber as filler with epoxy resin as a matrix using hand layup technique.
Findings
Then, tensile, flexural and compressive strength and water absorption tests were conducted on sodium hydroxide treated and untreated fiber composites. The test results comparing with and without alkali treated composites show that there was significant change in their strength and water absorption properties on alkali treated fiber.
Originality/value
This study is an original research paper.