Search results

The current study aims to propose a new analytical approach by considering energy consumption (EC), maximum tardiness and completion time as the primary objective functions to assess the performance of parallel, non-bottleneck and multitasking machines operating in dynamic job shops.

An analytical and iterative method is presented to optimize a novel dynamic job shop under technical constraints. The machine’s performance is analyzed by considering the setup energy. An optimization model from initial processing until scheduling and planning is proposed, and data sets consisting of design parameters are fed into the model.

Significant variations of EC and tardiness are observed. The minimum EC was calculated to be 141.5 hp.s when the defined decision variables were constantly increasing. Analysis of the optimum completion time has shown that among all studied methods, first come first served (FCFS), earliest due date (EDD) and shortest processing time (SPT) have resulted in the least completion time with a value of 20 s.

Considerable amount of energy can be dissipated when parallel, non-bottleneck and multitasking machines operate in lower-power modes. Additionally, in a dynamic job shop, adjusting the trend and arrangement of decision variables plays a crucial role in enhancing the system’s reliability. Such issues have never caught the attention of scientists for addressing the aforementioned problems. Therefore, with these underlying goals, this paper presents a new approach for evaluating and optimizing the system’s performance, considering different objective functions and technical constraints.

The purpose of this paper is to investigate the autoclave-pump pressured water distribution system. Pressured water is used in many manufacturing processes, as a raw material or as a service fluid for different applications.

The performances and the total installation costs of such systems are strongly related to its design and to its decision variables definition. The authors first identify the independent variables (i.e. the decision variables) and the dependent variables of the system and, second, propose a techno-economic mathematical method able to determine its minimum installation cost with an integrated approach.

The trade-off between the autoclave installation costs versus the pump installation costs is demonstrated. A sensitive analysis of the cost of the system as function of its decision variables has been performed to propose a practical graphical analysis tools to proper design the integrated pump-autoclave pressured water distribution system.

Many previous researches focus only on the pump system optimization or in the tank system optimization without an integrated approach. The wide utilization in industry of the autoclave-pump pressured water distribution system together with the lack of similar contributions in this area enforces the value of this research.

This study aims to evaluate the effects of betanin on AMP-activated protein kinase (AMPK), Sirtuin1 (SIRT1) and Sirtuin6 (SIRT6) gene expression as well as the tumour necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) cytokine release in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and healthy controls.

PBMCs isolated from whole blood of 50 patients with CAD and 48 healthy subjects aged 45 to 60 years were treated with 10 and 20 µM of betanin for 24 h. Real-time polymerase chain reaction was performed to assess gene expression levels of AMPK, SIRT1 and SIRT6. The supernatants of the cultured cells were used to assess the IL-6 and TNF-α protein levels by ELISA.

Treatment with both doses of betanin significantly increased AMPK, SIRT1 and SIRT6 expression in PBMCs of CAD patients compared to control non-treated cells (p < 0.05). In PBMCs of healthy subjects, only treatment with high dose of betanin showed significant increase in AMPK (p = 0.007), SIRT1 (p = 0.013) and SIRT6 (p = 0.024) expression compared to control non-treated cells. Betanin (20 µM) also significantly decreased TNF-α and IL-6 concentrations in the culture supernatants of the CAD patients compared to control non-treated cells (p < 0.001).

Betanin could enhance AMPK, SIRT1 and SIRT6 gene expressions in PBMCs and represent a useful complementary treatment to reduce the proinflammatory status accompanied with CAD.