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The purpose of this paper is to evaluate the role of handicraft production units within creative cultural clusters (CCCs) and their impact on urban regeneration, particularly within the historical fabric of Isfahan. It aims to identify the key factors contributing to the development of CCCs and how these clusters, in turn, influence tourism development.

The research method of this study is based on a quantitative approach, using a researcher-devised questionnaire as the primary data collection instrument. The statistical population included 227 units of handicraft makers in the historical fabric of Isfahan. The data processing and analysis were performed using SPSS software.

Statistical analysis confirms the creative industries, spatial and socio-cultural indices significantly impact tourism, with means of 14.19, 19.07 and 15.11. Clustering, cultural resources and tourism are key to CCCs growth, while innovation and cultural identity have less effect. CCCs enhance Isfahan’s historical fabric, improving urban space attractiveness and fostering social ties. Handicraft clusters around Naqsh-e Jahan square notably influence the economy and cultural identity, with shop placement reflecting the city’s character.

The originality of this research lies in its analysis of how handicraft production within CCCs contributes to urban regeneration and tourism in Isfahan, with a novel focus on the socio-cultural and economic impacts of these clusters in a historical context.