Moontaha Farin, Jarin Tasnim Maisha, Ian Gibson and M. Tarik Arafat
Additive manufacturing (AM), also known as three-dimensional (3D) printing technology, has been used in the health-care industry for over two decades. It is in high demand in the…
Abstract
Purpose
Additive manufacturing (AM), also known as three-dimensional (3D) printing technology, has been used in the health-care industry for over two decades. It is in high demand in the health-care industry due to its strength to manufacture custom-designed and personalized 3D constructs. Recently, AM technologies are being explored to develop personalized drug delivery systems, such as personalized oral dosages, implants and others due to their potential to design and develop systems with complex geometry and programmed controlled release profile. Furthermore, in 2015, the US Food and Drug Administration approved the first AM medication, Spritam® (Apprecia Pharmaceuticals) which has led to tremendous interest in exploring this technology as a bespoke solution for patient-specific drug delivery systems. The purpose of this study is to provide a comprehensive overview of AM technologies applied to the development of personalized drug delivery systems, including an analysis of the commercial status of AM based drugs and delivery devices.
Design/methodology/approach
This review paper provides a detailed understanding of how AM technologies are used to develop personalized drug delivery systems. Different AM technologies and how these technologies can be chosen for a specific drug delivery system are discussed. Different types of materials used to manufacture personalized drug delivery systems are also discussed here. Furthermore, recent preclinical and clinical trials are discussed. The challenges and future perceptions of personalized medicine and the clinical use of these systems are also discussed.
Findings
Substantial works are ongoing to develop personalized medicine using AM technologies. Understanding the regulatory requirements is needed to establish this area as a point-of-care solution for patients. Furthermore, scientists, engineers and regulatory agencies need to work closely to successfully translate the research efforts to clinics.
Originality/value
This review paper highlights the recent efforts of AM-based technologies in the field of personalized drug delivery systems with an insight into the possible future direction.
Details
Keywords
M. Tarik Arafat, Ian Gibson and Xu Li
This paper aims to review the advances in additive manufactured (AM) scaffolds for bone tissue engineering (TE). A discussion on the state of the art and future trends of bone TE…
Abstract
Purpose
This paper aims to review the advances in additive manufactured (AM) scaffolds for bone tissue engineering (TE). A discussion on the state of the art and future trends of bone TE scaffolds have been done in terms of design, material and different AM technologies.
Design/methodology/approach
Different structural features and materials used for bone TE scaffolds are evaluated along with the discussion on the potential and limitations of different AM scaffolds. The latest research to improve the biocompatibility of the AM scaffolds is also discussed.
Findings
The discussion gives a clear understanding on the recent research trend in bone TE AM scaffolds.
Originality/value
The information available here would be useful for the researchers working on AM scaffolds to get a quick overview on the recent research trends and/or future direction to work on AM bone TE scaffolds.
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Wenxiong Lin, Huagang Liu, Haizhou Huang, Jianhong Huang, Kaiming Ruan, Zixiong Lin, Hongchun Wu, Zhi Zhang, Jinming Chen, Jinhui Li, Yan Ge, Jie Zhong, Lixin Wu and Jie Liu
The purpose of this paper is to explore the possibility of an enhanced continuous liquid interface production (CLIP) with a porous track-etched membrane as the oxygen-permeable…
Abstract
Purpose
The purpose of this paper is to explore the possibility of an enhanced continuous liquid interface production (CLIP) with a porous track-etched membrane as the oxygen-permeable window, which is prepared by irradiating polyethylene terephthalate membranes with accelerated heavy ions.
Design/methodology/approach
Experimental approaches are carried out to characterize printing parameters of resins with different photo-initiator concentrations by a photo-polymerization matrix, to experimentally observe and theoretically fit the oxygen inhibition layer thickness during printing under conditions of pure oxygen and air, respectively, and to demonstrate the enhanced CLIP processes by using pure oxygen and air, respectively.
Findings
Owing to the high permeability of track-etched membrane, CLIP process is demonstrated with printing speed up to 800 mm/h in the condition of pure oxygen, which matches well with the theoretically predicted maximum printing speed at difference light expose. Making a trade-off between printing speed and surface quality, maximum printing speed of 470 mm/h is also obtained even using air. As the oxygen inhibition layer created by air is thinner than that by pure oxygen, maximum speed cannot be simply increased by intensifying the light exposure as the case with pure oxygen.
Originality/value
CLIP process is capable of building objects continuously instead of the traditional layer-by-layer manner, which enables tens of times improvement in printing speed. This work presents an enhanced CLIP process by first using a porous track-etched membrane to serve as the oxygen permeable window, in which a record printing speed up to 800 mm/h using pure oxygen is demonstrated. Owing to the high permeability of track-etched membrane, continuous process at a speed of 470 mm/h is also achieved even using air instead of pure oxygen, which is of significance for a compact robust high-speed 3D printer.