Search results

Clinical evidence has suggested that alpha-lipoic acid (ALA), a potent antioxidant, seems to have some effects on inflammatory process. However, these results are equivocal. The purpose of this paper is to investigate the nature of association between ALA and serum C-reactive protein (CRP) level by pooling the results from clinical trial studies.

Relevant studies were identified by systematic literature search of PubMed/MEDLINE, Scopus, Web of Sciences and Cochrane library up to September 2016 for randomized controlled trials (RCTs) evaluating the impact of ALA supplementation on CRP. The pooled data were summarized as weighted mean difference (WMD) and 95 per cent confidence interval (CI). Effect sizes of eligible studies were pooled using random- or fixed-effects (the DerSimonian–Laird estimator) depending on the results of heterogeneity tests.

Of 212 papers, 15 were eligible RCTs according to inclusion criteria. The selected studies comprised 1,408 cases and 457 controls. The dose of ALA supplement ranged from 300 to 1,200 mg, and the duration of follow-up was from 1 to 48 weeks. ALA supplementation significantly reduced the levels of circulating CRP (WMD: −0.088, 95 per cent CI: −0.131, −0.045, p < 0.001) with significant heterogeneity (I² = 73.4 per cent, p < 0.001). Populations with age younger than 50 years (PMD: −0.060 mg/dl), receiving doses less than 600 mg/day (PMD: −0.057 mg/dl), having cardiovascular disease (PMD: −0.105 mg/dl), hemodialysis (PMD: −0.209 mg/dl), diabetes (PMD: −0.021 mg/dl) and otherwise healthy subjects (PMD: −0.045 mg/dl) were sources of heterogeneity.

This meta-analysis of RCTs suggests that ALA supplementation seems to significantly reduce circulating CRP level.

Recent research has suggested the beneficial effects of omega-3 fatty acids on kidney function; however, differences in these benefits have not been well-documented with respect to different omega-3 fatty acid sources. Hence, the purpose of this study is to compare the effects of plants, marine sources of omega-3 fatty acids and their combination on biomarkers of renal function in overweight and obese individuals.

Ninety-nine overweight and obese women from a weight loss clinic received three weight-reducing diets with fish (300 g/week), walnuts (18 walnuts/week) or fish + walnuts (150 g fish + 9 walnuts/week) for 12 weeks. Serum biomarkers of renal function were measured at the beginning and the end of the intervention.

After 12 weeks, a reduction in serum creatinine was statistically higher for both the fish + walnut (−0.16 ± 0.09 mg/dL, p = 0.001) and walnut (−0.15 ± 0.05 mg/dL, p = 0.001) diets compared with the fish diet (−0.05 ± 0.04 mg/dL). A significant decrease was seen in blood urea nitrogen (BUN) level in the fish + walnut group (−0.12 ± 0.05 mg/dL, p = 0.03) and walnut group (−0.10 ± 0.04 mg/dL, p = 0.03) compared to the fish group (−0.05 ± 0.03 mg/dL). The effect of serum creatinine and BUN in the fish + walnut diet group was relatively higher than in the walnut diet group. Also, a significant difference was observed regarding weight loss in the fish + walnut diet (−7.2 ± 0.9 kg, p = 0.03) compared to in the other groups. The change in other indices was not different among the three diets.

This study found synergistic benefits of the plant and marine omega-3 fatty acids in reducing serum creatinine, BUN and weight compared with isolated marine omega-3s in overweight and obese women.

There is limited knowledge about the association of food insecurity and dietary quality among the Iranian households. The purpose of this study is to determine diet quality among the Iranian households and to investigate whether dietary quality is associated with food security status in this population.

The 18-item household food security questionnaire was administered to 200 households from different parts of Isfahan, Iran. Households were selected by two-stage cluster randomized sampling. Households were categorized into four groups based on their score on the questionnaire; food secure (total score 0), mild food insecure (total score 1–2), moderate food insecure (total score 3–7) and severe food insecure (total score 8–18). In the second stage of the study, 25 households were selected from each food security status group to evaluate the micronutrient adequacy and assess the adherence to Alternative Healthy Eating Index 2010 (AHEI-2010).

Food-secure households had higher adherence to the AHEI-2010 than food-insecure households (p < 0.001). Food-secure households consistently achieved higher value of the nutrient adequacy ratio for most of the micronutrients than food-insecure households, with the greatest differences seen for zinc (p < 0.001) in households (father, mother and first child), vitamin D (p < 0.001), vitamin A (father: p = 0.05, mother: p = 0.04), calcium (p < 0.001) and iron (father: p = 0.02, mother: p < 0.001) in mother and father.

Low dietary quality was associated with food insecurity. Food-secure households had higher micronutrient adequacy ratio for most of the nutrients.

The purpose of this paper is to describe reliability and relative validity of the short-food frequency questionnaire (SH-FFQ) used for assessing food groups and nutrient intakes of Iranian adults.

The food list used in the SH-FFQ was elaborated based on a dietary survey of a sample of 60 individuals aged between 15 and 65 years. A total of 180 subjects (93 males and 87 females) were included in the study. All participants completed two SH-FFQs with one month interval, a single 24 hours recall (24hR) and two food records for three non-consecutive days.

No significant differences were observed in the mean daily intakes of energy, food groups and most of the nutrients between the reference tools and the two semi-quantitative SH-FFQs (p>0.05). The mean energy-adjusted reliability coefficients for all variables were 0.54 and 0.55 in men and women. The mean energy-adjusted and deattenuated correlation coefficients for all items between the SH-FFQ and reference tools were 0.54. Also, the mean percent misclassified into opposite quartiles for all food groups and nutrients was 12.6 percent.

The designed SH-FFQ developed for the Life style Promotion Project has reasonable reliability and relative validity for food groups and nutrient in Iranian adults.