The purpose of this paper is to review the efficacy of atypical antipsychotics in combination with clozapine. Previous meta-analyses have assessed the use of both typical and…
Abstract
Purpose
The purpose of this paper is to review the efficacy of atypical antipsychotics in combination with clozapine. Previous meta-analyses have assessed the use of both typical and atypical antipsychotics in combination with clozapine, combination treatment being withheld only for those patients deemed treatment resistant.
Design/methodology/approach
Outcomes assessed included: positive, negative and overall symptom score. The total numbers of participants (n=588) were scored using the Positive and Negative Symptom Scale/the Brief Psychiatric Rating Scale and effect sizes were used to judge the efficacy of the combination treatments. Data gained from the ten randomized, double blind, placebo controlled trials were analysed using the R statistical software.
Findings
The effect sizes gained from analysis showed a small benefit of combination therapy over clozapine monotherapy. Therefore, it is the recommendation of this analysis that alternative avenues be sought in order to treat patients who have a sub-optimal response to clozapine with a combination other than two second generation antipsychotics.
Research limitations/implications
The initial trials search unveiled 1,412 studies. After the inclusion and exclusion criteria were applied, ten trials were used in this meta-analysis.
Practical implications
The recommendation of this analysis that alternative medications be sought in order to treat patients who have a sub-optimal response to clozapine with a combination other than two second generation antipsychotics. This route should only be used once all other treatment options have been exhausted.
Originality/value
This meta-analytical study looks specifically at the combination of atypical antipsychotics with clozapine in comparison to clozapine monotherapy. This work extends existing meta-analysis by incorporating data from more recent trials.
Details
Keywords
David M. Andrus, Edward Silver and Dallas E. Johnson
The study identifies major factors that contrast gift decisions for different status signature clothes. Gift buying represents a significant proportion of purchases in many…
Abstract
The study identifies major factors that contrast gift decisions for different status signature clothes. Gift buying represents a significant proportion of purchases in many product classes and is a pervasive retail consumption pattern. Specialty clothing retail sales surpassed the $9 billion figure in 1983. Factors that discriminate status brands for gift purchases can be used to develop market strategies to increase purchases. Strategies are provided for brand managers, fashion marketers, and store buyers to better meet consumer needs and wants in the gift‐buying process.
This paper shows that the collector (like the flâneur) is a decisive character in Walter Benjamin’s philosophy of history, specifically in the manifestation of the historical…
Abstract
Purpose
This paper shows that the collector (like the flâneur) is a decisive character in Walter Benjamin’s philosophy of history, specifically in the manifestation of the historical materialist, yet the paper is not so much about the collector or collecting as it is about the commodity and the experience thereof in consumer society.
Methodology/approach
The section “The Dream World of Mass Culture” discusses mass culture and the central problem of commodity fetishism as Benjamin sees it. The section “A Physiognomist of ‘the World of Things’” discusses the critical task of the historical materialist actualized and made possible through an activity akin to collecting. The section “Collecting, Child’s Play, and Seeing Similarities” illuminates the central importance of the activity of collecting for Benjamin’s research regarding mass culture, historical materialism, and the experience of modernity itself. The final section explains and fleshes out the central concepts of the mimetic faculty and physiognomic perception for Benjamin.
Findings
I find that, ultimately, to understand the ability of the historical materialist to witness history critically, according to Benjamin, is to understand the historical materialist as a collector. To understand the revolutionary activity of collecting is to understand collecting as a manifestation of a fundamental activity of human nature, the inclination to become “like” or to become “similar.” But such an impulse grounds, for Benjamin, not only the activity of collecting but also collective experience, the collective conscious, mass culture, and the essence of the commodity itself as a sociocultural artifact. The paper demonstrates that the mimetic faculty is the primary human faculty Benjamin focused on in his theory of experience.
Originality/value
The originality of this paper lies in the fact that it illustrates the primary importance of the theory of the mimetic faculty, the notion of physiognomic perception, and the work of Heinz Werner to Walter Benjamin’s theory of commodity fetishism that to date has been largely underdeveloped. But, more importantly, the paper shows that Benjamin’s theory of experience could illuminate a path toward developing a theory of experience within a fundamental philosophical anthropology.