Kevin Erhart, Eduardo Divo and Alain Kassab
This paper aims to develop and describe an improved process for determining the rate of heat generation in living tissue.
Abstract
Purpose
This paper aims to develop and describe an improved process for determining the rate of heat generation in living tissue.
Design/methodology/approach
Previous work by the authors on solving the bioheat equation has been updated to include a new localized meshless method which will create a more robust and computationally efficient technique. Inclusion of this technique will allow for the solution of more complex and realistic geometries, which are typical of living tissue. Additionally, the unknown heat generation rates are found through genetic algorithm optimization.
Findings
The localized technique showed superior accuracy and significant savings in memory and processor time. The computational efficiency of the newly proposed meshless solver allows the optimization process to be carried to a higher level, leading to more accurate solutions for the inverse technique. Several example cases are presented to demonstrate these conclusions.
Research limitations/implications
This work includes only 2D development of the approach, while any realistic modeling for patient‐specific cases would be inherently 3D. The extension to 3D, as well as studies to improve the technique by decreasing the sensitivity to measurement noise and to incorporate non‐invasive measurement positioning, are under way.
Practical implications
As medical imaging continuously improves, such techniques may prove useful in patient diagonosis, as heat generation can be correlated to the presence of tumors, infections, or other conditions.
Originality/value
This paper describes a new application of meshless methods. Such methods are becoming attractive due to their decreased pre‐processing requirements, especially for problems involving complex geometries (such as patient specific tissues), as well as optimization problems, where geometries may be constantly changing.
Details
Keywords
Jonathan A. Batten and Peter G. Szilagyi
Emerging financial markets have largely proven resilient to the consequences of the Global Financial Crisis. While this owes much to the bitter experience and economic strategies…
Abstract
Emerging financial markets have largely proven resilient to the consequences of the Global Financial Crisis. While this owes much to the bitter experience and economic strategies developed and implemented following the Asian Financial Crisis of 1997–1998, providence also played a hand in that relatively few of its financial institutions were exposed to the complex structured products that underpinned the demise of many financial intermediaries in the United States and Europe. The objective of this volume is to investigate and assess the impact and response to the crisis in emerging markets from a number of perspectives. These include asset pricing, contagion, financial intermediation, market structure and regulation. Our hope is that the assembled chapters offer clear insights into the complex financial arrangements that now link emerging and developed financial markets in the current economic environment. The volume spans four dimensions: first, a series of background studies offer explanations of the causes and impacts of the crisis on emerging markets more generally; then, implications are considered. The third and final sections provide insights from regional and country-specific perspectives.