The purpose of this paper is to review the efficacy of atypical antipsychotics in combination with clozapine. Previous meta-analyses have assessed the use of both typical and…
Abstract
Purpose
The purpose of this paper is to review the efficacy of atypical antipsychotics in combination with clozapine. Previous meta-analyses have assessed the use of both typical and atypical antipsychotics in combination with clozapine, combination treatment being withheld only for those patients deemed treatment resistant.
Design/methodology/approach
Outcomes assessed included: positive, negative and overall symptom score. The total numbers of participants (n=588) were scored using the Positive and Negative Symptom Scale/the Brief Psychiatric Rating Scale and effect sizes were used to judge the efficacy of the combination treatments. Data gained from the ten randomized, double blind, placebo controlled trials were analysed using the R statistical software.
Findings
The effect sizes gained from analysis showed a small benefit of combination therapy over clozapine monotherapy. Therefore, it is the recommendation of this analysis that alternative avenues be sought in order to treat patients who have a sub-optimal response to clozapine with a combination other than two second generation antipsychotics.
Research limitations/implications
The initial trials search unveiled 1,412 studies. After the inclusion and exclusion criteria were applied, ten trials were used in this meta-analysis.
Practical implications
The recommendation of this analysis that alternative medications be sought in order to treat patients who have a sub-optimal response to clozapine with a combination other than two second generation antipsychotics. This route should only be used once all other treatment options have been exhausted.
Originality/value
This meta-analytical study looks specifically at the combination of atypical antipsychotics with clozapine in comparison to clozapine monotherapy. This work extends existing meta-analysis by incorporating data from more recent trials.
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This paper aims to offer a profile of domestic abuse of older women and its impact on their health and well-being; explore some of the conceptual tensions that exist in this…
Abstract
Purpose
This paper aims to offer a profile of domestic abuse of older women and its impact on their health and well-being; explore some of the conceptual tensions that exist in this field; and discuss current policy and practice responses to this group of victim-survivors.
Design/methodology/approach
It is a review paper drawing on material from a range of sources; it has policy, practice and research implications.
Findings
Although there is growing recognition that older women are victims of domestic abuse, it tends to be regarded as a “younger women’s issue” and to be subsumed under the umbrella of elder abuse. This not only removes the gendered element, but it also uncouples it from the lifecourse where, for many, its roots lie. It also tends to foreground “old age” as the primary dimension of risk. There is a tension between the justice-oriented approach of the domestic abuse system and the welfarist approach that imbues the safeguarding system. There is a need for integration between the two systems. Also, for the health and care system to be more alert to the needs of older women at risk, we need to achieve a more effective balance between protection and justice, accord a greater level of agency to older victim-survivors and ensure they have access to domestic abuse law, policy and appropriate support services.
Research limitations/implications
More research is needed with older victim-survivors: listening to their lived experiences, coping strategies and pathways out of abuse. The issue also needs to be more visible.
Practical implications
Developing appropriate domestic abuse services for older women is critical. Practice lessons can be learnt too: especially greater integration of the safeguarding system with the domestic abuse system. Training is needed too for frontline health and social care staff about the distinctive nature of domestic abuse of older women.
Social implications
Domestic abuse of older women needs to be spoken about and made more visible in society and inside services, including older people’s third sector services.
Originality/value
This paper adopts a critical lens and makes a number of new arguments.
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Communications regarding this column should be addressed to Mrs. Cheney, Peabody Library School, Nashville, Term. 37203. Mrs. Cheney does not sell the books listed here. They are…
Abstract
Communications regarding this column should be addressed to Mrs. Cheney, Peabody Library School, Nashville, Term. 37203. Mrs. Cheney does not sell the books listed here. They are available through normal trade sources. Mrs. Cheney, being a member of the editorial board of Pierian Press, will not review Pierian Press reference books in this column. Descriptions of Pierian Press reference books will be included elsewhere in this publication.
To contribute to and evoke ongoing reflections on librarians' professional identity, i.e. librarianship. Inherent hereto is a questioning of the feasibility of collections and…
Abstract
Purpose
To contribute to and evoke ongoing reflections on librarians' professional identity, i.e. librarianship. Inherent hereto is a questioning of the feasibility of collections and collections control as basic constituents hereof. Instead, it is argued that an inquiry into proprieties of librarians' actual and potential tools allows for establishing firmer grounds for present and future librarianship.
Design/methodology/approach
In a number of analytical steps, the concept of librarianship is deconstructed.
Findings
Collections and collections control are shown to equal conceptual quicksand for librarianship at a time where access to information is largely outside librarians' control. Alternatively, an understanding of actual and potential librarians' tools may potentially provide firmer conceptual basis.
Practical implications
It is suggested that librarians are to reflect critically on the appropriateness of actual and potential tools applied.
Originality/value
Questions whether collections and collections control constitute a feasible primary constituent for librarianship. Suggests, instead, that firmer conceptual grounds for librarianship are to be established.
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Cláudia Barbosa, Filipa Borrego, Teresa Costa, Ana Ferreira, Madalena Martins, Susana Moreira, José M. R. C. A. Santos and José Avelino Silva
This chapter addresses the profession of research management and administration (RMA) in Portugal. It starts with a brief outline of the national research and innovation (R&I…
Abstract
This chapter addresses the profession of research management and administration (RMA) in Portugal. It starts with a brief outline of the national research and innovation (R&I) ecosystem that contextualises the development of the profession. The RMA community is characterised and the expectations for the future of the RMA profession are summarised using data collected through a national online survey. It is posited that RMA in Portugal is an emergent career having developed key traits of a profession, namely common interests and practices, a concern with deepening specialised knowledge and skills, the existence of an organised network of practitioners, the offer of academic qualifications and training in the area, and the integration in international RMA communities of practice. Nevertheless, future developments in the European Research Area (ERA) are identified as a critical milestone that will influence the development and formal legislative institutionalisation of the RMA profession in Portugal.
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Ken Butcher, Beverley Sparks and Frances O’Callaghan
Four attitudinal components of customer loyalty were synthesised from the services literature and combined to produce a loyalty conceptualisation that excludes repurchase…
Abstract
Four attitudinal components of customer loyalty were synthesised from the services literature and combined to produce a loyalty conceptualisation that excludes repurchase behaviour. This proposed conceptualisation of service loyalty was then modelled in two quantitative studies to determine the effects of potential predictors. The influence of consumers’ evaluative judgements was compared against the effects of relational outcomes. The three evaluative judgement measures were service encounter satisfaction, perceived core service quality and value for money while relational measures comprised social comfort, social regard and friendship. It was found that while personal friendship between customer and service employee was significantly associated with loyalty, service encounter satisfaction was the major predictor. It was also found that the relational factors of social comfort and social regard played indirect roles through their influence on customer’s evaluation of satisfaction and quality. Conversely, friendship was not related to the mediating variables of service encounter satisfaction and perceived core service quality.
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This progress report attempts to chart the main trends in professional education during the 1970s and to identify the major problems facing curriculum planners for the rest of…
Abstract
This progress report attempts to chart the main trends in professional education during the 1970s and to identify the major problems facing curriculum planners for the rest of this decade—and beyond. Although the work is based on United Kingdom educational practice, developments in other countries are noted whenever it is felt that a helpful comparison may be made. The citations do not represent a bibliography of professional education: such a compilation has already been accomplished in the researches of Burrell, and to a lesser extent in Clough. Writings on professional education in librarianship and information science tend to date rather quickly; especially if they deal with information technology or technical services. Theoretical problems remain more durable and usually reappear in different guises. Both information science and librarianship are bracketed together whenever they interrelate or overlap, or whenever logic and common sense dictate. In no way is it implied that they are both one and the same thing; the terms denote different areas of professional application and activity.
This paper examines a user categorisation of documents related to a particular literary work. Fifty study participants completed an unconstrained sorting task of documents related…
Abstract
This paper examines a user categorisation of documents related to a particular literary work. Fifty study participants completed an unconstrained sorting task of documents related to Charles Dickens’ A Christmas carol. After they had finished the sorting task, participants wrote descriptions of the attributes they used to create each group. Content analysis of these descriptions revealed categories of attributes used for grouping. Participants used physical format, audience, content description, pictorial elements, usage, and language most frequently for grouping. Many of the attributes participants used for grouping already exist in bibliographic records and may be used to cluster records related to works automatically in online catalogue displays. The attributes used by people in classifying or grouping documents related to a work may be used to guide the design of summary online catalogue work displays.
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THE following list of contracts placed by the Air Ministry during August is extracted from the September issue of The ministry of Labour Gazette: