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This paper aims to delve into the complexities of terminology mapping and annotation, particularly within the context of the COVID-19 pandemic. It underscores the criticality of harmonizing clinical knowledge organization systems (KOS) through a cohesive clinical knowledge representation approach. Central to the study is the pursuit of a novel method for integrating emerging COVID-19-specific vocabularies with existing systems, focusing on simplicity, adaptability and minimal human intervention.

A design science research (DSR) methodology is used to guide the development of a terminology mapping and annotation workflow. The KNIME data analytics platform is used to implement and test the mapping and annotation techniques, leveraging its powerful data processing and analytics capabilities. The study incorporates specific ontologies relevant to COVID-19, evaluates mapping accuracy and tests performance against a gold standard.

The study demonstrates the potential of the developed solution to map and annotate specific KOS efficiently. This method effectively addresses the limitations of previous approaches by providing a user-friendly interface and streamlined process that minimizes the need for human intervention. Additionally, the paper proposes a reusable workflow tool that can streamline the mapping process. It offers insights into semantic interoperability issues in health care as well as recommendations for work in this space.

The originality of this study lies in its use of the KNIME data analytics platform to address the unique challenges posed by the COVID-19 pandemic in terminology mapping and annotation. The novel workflow developed in this study addresses known challenges by combining mapping and annotation processes specifically for COVID-19-related vocabularies. The use of DSR methodology and relevant ontologies with the KNIME tool further contribute to the study’s originality, setting it apart from previous research in the terminology mapping and annotation field.