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This research aims to examine the relationship between the physical environment and neuropsychological perception in children with Asperger’s disorder.

This study through mixed qualitative–quantitative approaches conducted strategies including a survey and case study. Accordingly, multiple methods were applied to collect data including semi-structured expert interviews (20 persons) and questionnaires (N = 400). The sampling strategy of questionnaire participants was random clustering and the target population was children with Asperger from Iran Asperger Support Associations. Besides, the sampling strategy for the participants of semi-structured expert interviews was non-random and purposeful. The collected data from the participant’s questionnaires and interviews were analyzed by Porsline and Excel software and content analysis, respectively.

Based on the relationship between the physical environment and neuropsychological perception, the results of the research indicate that despite all existing differences between the two spectra of hyper-sensitive and hypo-sensitive behaviors, it is possible to design architectural spaces responding to their common needs and satisfy both spectra.

This research on to healing aspect is quite new and contributes significant information about health issues in building design. This study tries to derive and examine the supportive characteristics of architectural spaces that integrate special physical and effective designs to improve the healing process of children with Asperger’s disorder.