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The purpose of this paper is to present an innovative approach for the development of a methodology to systematically assess the economic performance and for the assessment of the economic sustainability of a building, through the calculation of an economic sustainability index, within the sustainability framework according to the rules defined in EN 16627.

The methodology follows the principle of modularity, where aspects and impacts that influence the economic performance of the building during the phases of its life cycle are assigned to levels. It presents a model based on the construction costs of the building. The methodology in centered in the before use phase and restricted to residential buildings.

Definition of a model for assessing the economic performance and calculation of an economic sustainability index.

The methodology is focused only in the before use phase of the buildings, assuming they have the same functional equivalent. It can be expanded to include the other phases of the building life cycle.

The developed methodology will allow the selection of construction procedures, based on economic sustainability, contributing to more rational and support decisions.

Contributing to a more sustainable society.

The European framework of EN 15643 and EN 16627 for the assessment of building sustainability is new and, as such, not implemented in most practical tools. Also, economic sustainability is not usually considered in detail in existing models. This paper presents a methodology following the framework and, simultaneously, possible to integrate in existing approaches.

This paper aims to highlight the political influences that account for the destination image of a tourist city: Campos do Jordão, São Paulo State, Brazil. The study took into consideration the collective imagination and its influence on the formation of touristic destinations.

Descriptive study based on literature and document review, accompanied by an analysis of texts and photos available on non-official websites – about Campos do Jordão – from November to December 2018 and by visits to selected location.

“Charm”, “refinement” and “sophistication” are the most frequently used words to describe Campos do Jordão, which remains a symbol of exclusiveness and refuge for the highest social classes. These images are shaped by political and economic influences.

The investigation focussed on a single city. Also, as it is an analytical study aimed at showing the permanence of preconceived values used to build the image of a destination it is not possible to talk about extrapolating the present study to other cities. In addition, the research was done by using the reproduction of physical and cultural aspects in addition to the use of European landscapes structures and values in a locality with an exceptional environmental context.

Many of the images connected to Campos do Jordão are replicated by local citizens, a fact that evidences the importance of associative memory, which concerns memories citizens have of their living space. The social implications presented herein seek to recover the formative memories of the assessed city, although it is not the focus of the current study. Assumingly, becoming an active segment of the tourism sector is the only way for local citizens to appropriate the city.

The influence of local government and public actions in tourism construction and in the image linked to the city is used as a case study. Building a touristic imagination demands a wide range of businesses, but this process takes time and effort, as highlighted by the applied documental review; it would not happen without the straight interference of the public sector through the local government.

Recently, powerful instruments for biomedical engineering research studies, including disease modeling, drug designing and nano-drug delivering, have been extremely investigated by researchers. Particularly, investigation in various microfluidics techniques and novel biomedical approaches for microfluidic-based substrate have progressed in recent years, and therefore, various cell culture platforms have been manufactured for these types of approaches. These microinstruments, known as tissue chip platforms, mimic in vivo living tissue and exhibit more physiologically similar vitro models of human tissues. Using lab-on-a-chip technologies in vitro cell culturing quickly caused in optimized systems of tissues compared to static culture. These chipsets prepare cell culture media to mimic physiological reactions and behaviors.

The authors used the application of lab chip instruments as a versatile tool for point of health-care (PHC) applications, and the authors applied a current progress in various platforms toward biochip DNA sensors as an alternative to the general bio electrochemical sensors. Basically, optical sensing is related to the intercalation between glass surfaces containing biomolecules with fluorescence and, subsequently, its reflected light that arises from the characteristics of the chemical agents. Recently, various techniques using optical fiber have progressed significantly, and researchers apply highlighted remarks and future perspectives of these kinds of platforms for PHC applications.

The authors assembled several microfluidic chips through cell culture and immune-fluorescent, as well as using microscopy measurement and image analysis for RNA sequencing. By this work, several chip assemblies were fabricated, and the application of the fluidic routing mechanism enables us to provide chip-to-chip communication with a variety of tissue-on-a-chip. By lab-on-a-chip techniques, the authors exhibited that coating the cell membrane via poly-dopamine and collagen was the best cell membrane coating due to the monolayer growth and differentiation of the cell types during the differentiation period. The authors found the artificial membrane, through coating with Collagen-A, has improved the growth of mouse podocytes cells-5 compared with the fibronectin-coated membrane.

The authors could distinguish the differences across the patient cohort when they used a collagen-coated microfluidic chip. For instance, von Willebrand factor, a blood glycoprotein that promotes hemostasis, can be identified and measured through these type-coated microfluidic chips.