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The purpose of this study is to analyze markers of the progression of kidney damage by a soft computing approach.

Because markers of the progression of kidney damage, namely, plasminogen activator inhibitor-1 (PAI-1), interleukin-8 (IL-8) and highly sensitive troponin T (cTnhsT), are complex parameters, a soft computing approach was used for the assessment of functional glomerular reserves, through the use of the Modification of the Diet in Renal Disease (MDRD) formula based on serum creatinine and EPI creatinine-cystatin C formula (chronic kidney disease epidemiology collaboration).

The soft computing approach was used to detect which factors (PAI-1, IL-8 and cTnhsT) are the most important for the MDRD formula based on serum creatinine or the EPI creatinine–cystatin C formula.

Markers of the progression of kidney damage were analyzed by the soft computing approach.