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Depression and insomnia are very significant pathologies in cancer patients as they contribute to the patient's overall cure and quality of life. Moreover, untreated depression and ongoing insomnia are associated with decreased immune responses and lower survival rates. With all disease states and especially with cancer, close attention to drug-drug interactions and the potential impact on the efficacy of therapy is paramount. One area of particular interest due to the lack of well-done clinical trials is drug-drug interaction(s) between antidepressants and cancer treatment. Pharmacokinetics of a certain drug allows for prediction of certain drug interactions based on chemical properties of the agents involved. If the agents depend on their metabolites for activity, active drug level will be decreased through this enzyme inhibition. In this paper, we looked at the cytochrome-P450 drug interactions between antidepressants and sleep aids with Selective Estrogen Receptor Modulators (SERM). Newer SERM metabolisms are less influenced by interactions with medications used to treat depression. However, tamoxifen metabolism could be severely altered by several antidepressants. This has direct consequences as patients on tamoxifen and antidepressant can have double the risk of relapse to cancer in two years. We discussed those interactions and made recommendations for clinical use.

Communications regarding this column should be addressed to Mrs. Cheney, Peabody Library School, Nashville, Tenn. 37203. Mrs. Cheney does not sell the books listed here. They are available through normal trade sources. Mrs. Cheney, being a member of the editorial board of Pierian Press, will not review Pierian Press reference books in this column. Descriptions of Pierian Press reference books will be included elsewhere in this publication.

Il y a quelques années, nous avions fait un essai de regroupement des ressources touristiques à partir des éléments d'attraction qui motivent le déplacement du voyageur et indépendamment des facteurs qui pouvaient influencer son propre esprit. Il nous était apparu que toutes les ressources disponibles quelle que soit leur situation dans le Monde pouvaient se regrouper en 4 ensembles que nous avions intitulés Lithôme (les monuments), Phytôme (la Nature), Hydrôme (l'attirance de l'eau) et Anthropôme (les activités humaines).

This survey presents the recent and rapidly expanding literature, which analyses the economic impacts of the COVID-19 pandemic, by means of Computable General Equilibrium (CGE) modelling. It does so not only by contrasting and assessing the different methodological approaches, and the key findings of the simulation exercises, but also by putting the various contributions in a historical perspective. This is necessary because each CGE-based study should be evaluated while keeping in mind when it was realised, since questions, priorities, expectations have been constantly changing during the spreading of the pandemic.

WHEN A FRIEND OF MINE retired he had been like most businessmen, a reader of the lighter kind of book—thrillers, 'tecs, westerns—for evenings and weekends. Now he had most of the day for it, too, and I could see he was becoming surfeited with it.

In my preliminary thesis studies of social media, in the wake of the killings of women such as Natalie Connolly, there was a seeming widespread agreement, that if a man could get a relatively minor sentence for ending the life of a woman, using the purportedly ‘erotic’ context of the death as a legal means, then something in the judiciary was going wrong. Traditional feminists and many sex freedomists appeared to concur, in a rare moment of overlap on contemporary sexual ethics from these often scrummaging political groups. However, this ostensible concurring mystifies a more fundamental set of antagonisms that has plagued what we occasionally understand as the rhizomes of the ‘progressive left’, not least in the difficult relationship between political feminism and the sexual freedom movement, or indeed ‘sex positive feminism’. This latter ‘choice’ feminism seemingly elided with sexual freedom and jettisoned the hang ups of radical, Marxist and some branches of equality feminism, still persisting but indicative of what we broadly call ‘the second wave’. This elision between feminism and sexual freedom situates women as individuals with identities that signify an inexhaustible will, not as a casted and economized subjectivity embedded in a historical moment. This move sought to overcome the stalemate between sexual liberation, and women’s liberation. But did it? If we ask questions such as: what should legal practice and policy privilege in its functioning, the protection of individual sexual choices, or defence of the physical safety of women made vulnerable to violence by sexually oppressive cultures? – we may uncover the more profound ethical and epistemological contentions at stake. I want to frame the disputes between sexual freedomists and feminists that still persist, despite our contemporary liberal feminist vernacular, in relation to this theoretical shift in what is understood as ‘choice’, using the issues that satellite ‘the rough sex defence’ (BDSM, porn, violence, consent) in order to illuminate this tension. I want to use a materialist feminist analysis that retraces the concept of ‘choice’ in the feminist canon in order to analyse this elision in the context of the antagonisms between women’s liberation and sexual liberation. In tracing this ethical history I hope to contribute to an untangling of these unwieldy political notions in order to better confront the crystallized divisions in progressive sexual politics that contextualize the underlying disputes that frame the ‘the rough sex defence’. Doing so is necessary if we are to manage a more open, lucid conversation about what the role of the law is, or should be, in dealing with sex and violence in twenty-first century Britain.

The purpose of this article is to compare the effects of global competitive pressures on the UK and French B-schools' management systems through the lens of career ecosystems.

This is a qualitative inquiry employing in-depth, semi-structured interviews with 44 business school academics in the two countries.

This paper demonstrates the importance of top-down and bottom-up ecosystem influences for creating contrasting performance management systems in competitive B-schools in the two countries, to different outcomes for institutions and faculty careers.

The authors focus on faculty working in top business schools, which limits the generalizability of the findings. Future research could apply the ecosystem lens to other institutions and geographical areas to highlight best practices and evaluate their transferability across borders.

The study highlights alternative HR practices and potentially workable adjustments to current systems that could be envisaged in order to enhance performance of individuals and institutions without jeopardizing the chances of valuable human resources to bring their contributions to the success of B-schools.

This paper compares and contrasts different performance management systems, taking into account exogenous and endogenous influences on B-schools that operate in a highly competitive and rapidly changing global management education market.