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Nanotechnology promises to be the defining science of the 21st century. With its integration of the organic and inorganic worlds, it represents more than simply a continuation of the principles of microtechnology. Because of this it requires new structures of R&D management, and new communication processes. A number of recent foresight studies identify potential future applications for European industry and point to the strengths and weaknesses of Member States. But only new interdisciplinary research networks will enable Europe to harness the power of nanotechnology – or prepare its citizens for the benefits.