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The purpose of this paper is to describe a novel design workflow for the digital fabrication of custom-made orthoses (CMIO). It is intended to provide an easier process for clinical practitioners and orthotic technicians alike. It further functions to reduce the dependency of the operators’ abilities and skills.

The technical assessment covers low-cost three-dimensional (3D) scanning, free computer-aided design (CAD) software, and desktop 3D printing and acetone vapour finishing. To analyse its viability, a cost comparison was carried out between the proposed workflow and the traditional CMIO manufacture method.

The results show that the proposed workflow is a technically feasible and cost-effective solution to improve upon the traditional process of design and manufacture of custom-made static trapeziometacarpal (TMC) orthoses. Further studies are needed for ensuring a clinically feasible approach and for estimating the efficacy of the method for the recovery process in patients.

The feasibility of the process increases the impact of the study, as the great accessibility to this type of 3D printers makes the digital fabrication method easier to be adopted by operators.

Although some research has been conducted on digital fabrication of CMIO, few studies have investigated the use of desktop 3D printing in any systematic way. This study provides a first step in the exploration of a new design workflow using low-cost digital fabrication tools combined with non-manual finishing.

City–university partnerships (CUPs) are emerging as dynamic collaborations addressing urban challenges in various cities. This chapter delves into the transformative dynamics of the CUP in Valencia, particularly within the framework of the European Union (EU) Cities Mission. Valencia, a recognized leader, achieved the EU Mission Label in 2023, showcasing the success of its collaboration with the Polytechnic University of València (UPV). The Valencian CUP functions as a multi-faceted entity, serving as a knowledge powerhouse, an innovation catalyst in urban policies, and a vital educational space. The exploration unfolds various dimensions of the CUP’s impact, emphasizing its contributions to the city’s development model, innovation in urban policies, and transdisciplinary education. Examining collaborations and transformations leading to CUP creation and effective functioning through the multi-level perspective (MLP) framework illuminates a complexity of the CUP in Valencia. It also highlights the catalytic role of the EU Cities Mission in shaping CUP creation. In conclusion, the CUP in Valencia stands as a beacon of inspiration and a blueprint for global urban centers navigating the path toward climate neutrality. This chapter contributes valuable insights to the broader discourse on the transformative potential of CUPs, acknowledging the narrative as ongoing and calling for further research to uncover their full potential in shaping resilient and sustainable urban landscapes.