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A proposal for the addition of yeast in routine and clinical diets for optimal nutrition of human beings was made on the premiss of its salubrious effects in laboratory and farm animals. The strong points in favour of the supplement are its ancient use in brewery and bakery production for human consumption, its cultural acceptability and freedom from pathogenicity, allergenicity, toxicity or carcinogenicity. Recommendations for clinical trials with humans were made to confirm a list of tentative advantages obtained in trials with animals.