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This paper is an empirical investigation of the effect of knowledge, skills and entrepreneur competencies on the performance of micro-, small- and medium-sized enterprises (MSMEs) operating in Upper Sindh, Pakistan.

The data were collected from owners/managers of MSMEs operating in major cities of Upper Sindh. A total of 1,100 respondents were identified through snowball and social contacts tools. A total of 316 respondents permitted researchers to visit their firms and collecting data from them by a survey questionnaire.

The findings shows that entrepreneurial skills and networking have a positive and significant effect on entrepreneurial competency. Then, entrepreneurial skills, networking and entrepreneurial competency have a positive effect on enterprise performance. The findings show a significant mediation effect of entrepreneurial competency on the relationships between entrepreneurial skills and networking and enterprise performance.

This paper provides useful conclusion in understanding the entrepreneur’s characteristics and their impact on performance MSMEs, which is crucial for promoting entrepreneurial activities and for enhancing socio-economic conditions among low-income households located in Upper Sindh, Pakistan. The government must make preparation in organizing trade fairs, seminars and road shows on certain services/ products to which MSMEs’ entrepreneurs, consumers and suppliers might be invited to ease their connections.