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Digital transformation in nursing education is crucial for enhancing pedagogical practices and preparing future healthcare professionals for the rapidly evolving healthcare landscape. This chapter explores how the integration of digital technologies in higher education has revolutionising teaching methodologies and offered new opportunities to enhance learning experiences. It identifies gaps in digital learning modalities for undergraduate and postgraduate nursing students and discusses strategies to strengthen online literacy preparation and transition into the healthcare sector's digital transformation landscape and the 4th industrial era economy. The chapter examines best practices and challenges in digital transformation in nursing education such as blended learning environments, simulation and virtual reality, mobile learning applications and gamification strategies. Additionally, it addresses challenges in curriculum development including insufficient technological infrastructure, faculty training and development, assessment strategies and resistance to change among faculty and students. This chapter aims to provide insights and recommendations for educators, curriculum developers and policymakers in implementing successful digital transformation in nursing education.