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This chapter delves into the intricate evolution and challenges of regulatory frameworks within the global financial sector, spotlighting the dynamic interplay between technological advancements, globalization and the imperative for stringent regulatory compliance. Initially, it traces the historical lineage of financial regulation from its nascent stages, through pivotal transformations aimed at enhancing market stability and integrity, to contemporary paradigms that balance efficiency with systemic safety. The discourse navigates through various regulatory models – ranging from institutional and functional frameworks to the innovative “Twin Peaks” model – and their respective merits and challenges in aligning with the evolving financial landscape. Furthermore, the paper scrutinizes the multifaceted role of managerial accountability in fostering a culture of compliance, emphasizing proactive risk assessment, regulatory reporting and the integration of ethical considerations into corporate governance. Through an analytical lens, it explores how financial institutions can navigate the complexities of adherence to diverse regulatory mandates, thereby safeguarding financial stability while promoting growth and innovation. The narrative concludes by projecting future trajectories of regulatory frameworks, advocating for a harmonious blend of regulatory rigor and flexibility to accommodate the rapid pace of financial innovation and global interconnectedness.