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The study aims to identify the extent to which industry 4.0 (IR4.0) adoption impacts the sustainable manufacturing (SM) performance of the manufacturing industry, focusing on the comparative analysis between developed and developing economies amid coronavirus disease 2019 (COVID-19) pandemic.

The study proposes a conceptual model formed on seminal theories and literature using the cross-sectional design. For data collection, a purposive sampling method is used where 154 Malaysian (developing) and Australian (developed) manufacturing firms' data were collected. Partial least square-based structural equation modeling is employed to test the hypothesis and proposed research model.

This study finds that adoption of IR4.0 technologies does not directly influence the sustainability performance of the manufacturing industry, but rather the trajectories of SM (efficiency, flexibility, automation and big data and granularity) fully mediate the relationship between IR4.0 adoption and sustainability manufacturing performance. The comparative analysis between Australia and Malaysia shows no significant difference in the relationships or the framework; hence, the differences between developed and developing countries are not significant in this mechanism.

The study contributes to the insights of the managers regarding COVID-19 and the implementation of IR4.0 in the SM domain. The policymakers would further get better insights since the study pays attention to sustainable development goal, industry, innovation, infrastructure and responsible production.

Growing emphasis on long-term viability prompts researchers and industry professionals to collaborate on innovative approaches for sustainability and survival. Industry 4.0 (I4.0) technology's importance drives active adoption by firms amidst evolving business dynamics. This research examines the influence of I4.0 technologies on lean, agile resilient and green practices and their impact on supply chain performance.

Survey data from Pakistani manufacturing enterprises were analyzed using SMART PLS to explore the relationship between I4.0 technology, supply chain practices and supply chain performance.

I4.0 technologies significantly impact all practices, while agile and resilient supply chain approaches partially mediate the relationship with supply chain performance.

Insights from this research guide policymakers and business experts in implementing and managing lean, agile, resilient and green practices. Integrating these principles with digital technology solutions enhances supply chain performance.

This study advances understanding of the interplay between I4.0 technologies, practices and supply chain performance, providing a basis for further research and practical implications.