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Sedentary living and respiratory/cardiovascular diseases affect respiratory and peripheral muscles. Muscle training can prevent, improve and reverse these changes. Their research question suggests that precise nutraceutical administration can enhance antioxidant capacity and muscle function. This sudy aims to evaluate the impacto of an innovative nutraceutical on blood biomarkers such as essential aminoacids, antioxidants, lipid profile, and REDOX status in healthy individuals, stable Chronic Obstructive Pulmonary Disease (COPD) patients, and mechanically ventilated patients.

The authors designed a nutraceutical to assess its effects on serum amino acids, lipid profile, vitamins, minerals and reduction-oxidation function. Conducted at a high-complexity care hospital, a study with a non-equivalent group design compared pre- and post-treatment administration.

The 29 participants were categorized into healthy individuals (n = 10), chronic obstructive pulmonary disease (COPD) patients (n = 10) and COPD patients receiving mechanical ventilation in an intensive care unit (ICU, n = 9) due to exacerbation. Analyzing serum values of selected markers and components before and after nutraceutical intake revealed significant differences. Oxygen radical absorption capacity units significantly increased (p = 0.0051) in healthy individuals. Isoleucine, valine, phosphorus, magnesium and calcium levels significantly increased in the healthy group.

The small sample size and short duration limit the generalizability of results. The non-equivalent group design and lack of randomization may introduce bias, affecting reliability. Future research should involve larger, randomized controlled trials to confirm HIC1® benefits. Additionally, exploring long-term effects and optimal dosing in various populations, including different COPD stages and other chronic conditions, will provide more comprehensive insights. Despite these limitations, the study suggests promising implications for enhancing muscle function and antioxidant capacity through precise nutraceutical administration.

The administration of HIC1® demonstrates potential for improving antioxidant capacity and muscle function, particularly in sedentary individuals and those with respiratory or cardiovascular diseases. This study’s findings suggest that even short-term use of HIC1® can lead to significant increases in serum amino acids and other vital nutrients. Health practitioners should consider incorporating nutraceuticals like HIC1® into treatment plans for COPD patients and those requiring mechanical ventilation. Future research and clinical practice should explore optimal dosing and long-term benefits, potentially improving patient outcomes in chronic disease management.

The use of nutraceuticals like HIC1® could have a significant impact on public health, especially for vulnerable populations such as the elderly and those with chronic illnesses. Improving muscle function and antioxidant capacity can reduce dependence on intensive care, decrease the economic burden on healthcare systems and enhance patients’ quality of life. Additionally, access to effective nutraceutical treatments could democratize healthcare, providing an affordable complementary option for preventing and managing muscle and respiratory diseases, promoting healthy and active aging in society.

This study is pioneering in evaluating the effects of a specifically designed nutraceutical, HIC1®, on both healthy individuals and those with chronic respiratory conditions. By focusing on precise nutraceutical administration, it addresses the gap in research on non-pharmaceutical interventions for enhancing muscle function and antioxidant capacity. The findings provide valuable insights into the potential of HIC1® to improve clinical outcomes in COPD patients and those undergoing intensive care, offering a novel, natural and potentially cost-effective approach to complement traditional treatments and support overall health and well-being.

The widespread uptake of digital technology tools for online teaching and learning reached its peak during the nationwide lockdown triggered by the COVID-19 pandemic. It transformed the higher education institutions (HEIs) marketplace both in developed and developing countries. However, in this process of digital transformation, several HEIs, specifically from developing countries, faced major challenges. That threatened to affect their sustainability and performance. In this vein, this study conducts a bibliometric review to map the challenges during the COVID-19 pandemic and suggest strategies for HEIs to cope with post-pandemic situations in the future.

This comprehensive review encompasses 343 papers published between 2020 and 2023, employing a systematic approach that combines bibliometrics and content analysis to thoroughly evaluate the articles.

The investigation revealed a lack of published work addressing the specific challenges faced by the faculty members affecting their well-being. The study underscores the importance of e-learning technology adoption for higher education sustainability by compelling both students and teachers to rely heavily on social media platforms to maintain social presence and facilitate remote learning. The reduced interpersonal interaction during the pandemic has had negative consequences for academic engagement and professional advancement for both educators and students.

This has implications for policymakers and the management of HEIs, as it may prove useful in reenvisioning and redesigning future curricula. The paper concludes by developing a sustainable learning framework using a blended approach. Additionally, we also provide directions for future research to scholars.

This study has implications for policymakers and HEI management to rethink the delivery of future courses with a focus on education and institute sustainability. Finally, the research also proposes a hybrid learning framework for sustainability and forms a robust foundation for scholars in future research.

Demand planning (DP) is a key element of supply chain management (SCM) and is widely regarded as an important catalyst for improving supply chain performance. Regarding the availability of technology to process large amounts of data, artificial intelligence (AI) has received increasing attention in the DP literature in recent years, but there are no reviews of studies on the application of AI in supply chain DP. Given the importance and value of this research area, we aimed to review the current body of knowledge on the application of AI in DP to improve SCM performance.

Using a systematic literature review approach, we identified 141 peer-reviewed articles and conducted content analysis to examine the body of knowledge on AI in DP in the academic literature published from 2012 to 2023.

We found that AI in DP is still in its early stages of development. The literature is dominated by modelling studies. We identified three knowledge clusters for AI in DP: AI tools and techniques, AI applications for supply chain functions and the impact of AI on digital SCM. The three knowledge domains are conceptualised in a framework to demonstrate how AI can be deployed in DP to improve SCM performance. However, challenges remain. We identify gaps in the literature that make suggestions for further research in this area.

This study makes a theoretical contribution by identifying the key elements in applying AI in DP for SCM. The proposed conceptual framework can be used to help guide further empirical research and can help companies to implement AI in DP.