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This study investigated demographic factors, attitude and knowledge of persons with special needs towards COVID-19 in Nigeria between 12 May and 25 May 2020. This cross-sectional online survey was conducted among 72 persons with special needs purposively selected from the six geo-political zones in Nigeria. A questionnaire comprising questions on demographic information (three), knowledge (24) and attitude (28) towards COVID-19 was completed via Google forms by the participants (r=0.78). There were more males (51, 70.8%) than females (21, 29.2%) and the most common age group was 34-44 years (37.5%). The number of participants with a hearing impairment was 34 (47.2%) and the number with a visual impairment was 26 (36.1%). The results indicate adequate knowledge about the characteristics of COVID-19. It was found that 98.6% of the participants had heard about COVID-19; 94.4% were aware that COVID-19 is a contagious disease, 91.7% stated that COVID-19 is a virus and 88.9% reported correctly that the incubation period is 3-14 days. The knowledge about symptoms of COVID-19 among participants was high (x=2.63; participants obtained 87.8% of the total achievable score for these questions). The knowledge about prevention and control of COVID-19 among participants needs was very high (x=2.77; participants obtained 92.3% of the total achievable score for these questions). Attitude of participants towards the COVID-19 outbreak was positive and above average (x=2.84). However, participants reported that it is hard to get palliatives or financial support from others during COVID-19 lockdown (52.8%) and that they feel frustrated by the uncaring attitude of the government towards them during COVID-19 lockdown (55.6%). On this basis, counselling and social policy implications were suggested including the provision of palliatives by the government and the need for widespread enlightenment among individuals with special needs on prevention of COVID-19.