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The purpose of this paper is to verify the possibility of ultrasonic intensification of drug dissolution of cholesterol calculi of the gallbladder using conventional ultrasound frequency and intensity from 0.1 to 0.5 W/cm².

For research purposes, the physical model was developed containing pig bile, pig liver, pigskin, fat and muscles, as well as human cholesterol calculus removed by surgery and a drug with ursodeoxycholic acid.

The studies have shown the possibility of accelerating the drug dissolution of calculi of the gallbladder with ultrasound exposure. The ultrasound intensity of 0.4 W/cm² is the most preferable to intensify the dissolution of calculus.

The results will be used to advance with development of the device and methodology for ultrasonic intensification of drug dissolution of gallbladder calculi.