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Linkages play a strategic role in improving actor disposition and resource density in university–industry ecosystems. Due to the importance of interconnected ecosystems for the development of engaged universities, applying the service-dominant logic (SDL) perspective, the authors aim at developing theory on linkages that lead to a higher level of actor commitment and in turn result in increased actor disposition and greater resource density.

Data from semistructured interviews from four in depth case studies, known internationally as successful cases of university linkages development (Columbia Lab-to-Market Accelerator Network, Oxford University Innovation, Auckland Uniservices and the Münster Center for Interdisciplinarity), undergo qualitative analysis according to the Gioia methodology.

The results represent a contribution to the theory, as they highlight the strategic role of linkages in improving actor disposition and increasing resource density. Due to its shown importance, linkage is an element to be considered on its own in the innovation ecosystems configurations in the context of universities.

The results of the research have implications for university management, since they focus on how resources are mobilized and linked. The interactive roles of actors in ecosystems imply that the locus of value creation moves beyond the borders of the organization toward the linkages. Strategies for managing university–industry linkages (UIL) are presented.

To date there has not been sufficient theoretical or empirical contribution in the university–industry ecosystem context about the role of linkages to improve resource density through increased actor disposition.

Given their capacity to generate knowledge, universities can be the primary external source of knowledge and innovation for companies. Despite studies on the potential drivers of open innovation, the actors involved in these projects beyond academics and the most effective practices that universities follow for successful university–industry collaborations remain unclear. This study aims to identify the enablers and best practices universities follow to contribute to successful university–industry open innovation results, providing a conceptual framework for the management of such initiatives.

Articles from peer-reviewed academic journals identified in the Scopus and Web of Science databases were researched in this scoping review. The review used descriptive and thematic analyses and focused on 93 articles published between 2013 and 2023 that analysed universities’ enablers and practices for knowledge transfer to the industry.

Organisational factors, stakeholder attitudes, infrastructure, and external factors facilitate knowledge transfer from universities to companies. The most effective practices for promoting innovation are related to project management, policies and incentives and are relational and educational. Performance results can be evaluated through quantitative and qualitative indicators, measured at the different phases of the innovation process, considering the impacts achieved.

Previous reviews have focused on barriers, researchers’ motivations or specific enablers. The enablers and practices identified were analysed with a systemic vision, considering the university as a unit of analysis. This study suggests a comprehensive conceptual framework for the successful management of university–industry open innovation.