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Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that is difficult to diagnose accurately due to its heterogeneous clinical manifestations. Comprehensive models combining different big data approaches (e.g. neuroimaging, genetics, eye tracking, etc.) may offer the opportunity to characterize ASD from multiple distinct perspectives. This paper aims to provide an overview of a novel diagnostic approach for ASD classification and stratification based on these big data approaches.

Multiple types of data were collected and recorded for three consecutive years, including clinical assessment, neuroimaging, gene mutation and expression and response signal data. The authors propose to establish a classification model for predicting ASD clinical diagnostic status by integrating the various data types. Furthermore, the authors suggest a data-driven approach to stratify ASD into subtypes based on genetic and genomic data.

By utilizing complementary information from different types of ASD patient data, the proposed integration model has the potential to achieve better prediction performance than models focusing on only one data type. The use of unsupervised clustering for the gene-based data-driven stratification will enable identification of more homogeneous subtypes. The authors anticipate that such stratification will facilitate a more consistent and personalized ASD diagnostic tool.

This study aims to utilize a more comprehensive investigation of ASD-related data types than prior investigations, including proposing longitudinal data collection and a storage scheme covering diverse populations. Furthermore, this study offers two novel diagnostic models that focus on case-control status prediction and ASD subtype stratification, which have been under-explored in the prior literature.

This paper aims to investigate the photocatalytic activity of zinc doped MAO-TiO₂ films under the optimum MAO treatment condition.

The coating was prepared by micro arc oxidation, and the influence of doping on the properties of the coating was also investigated.

The results show that the BET surface area is 78.25±0.03m²/g, total pore area is 76.32 ± 0.04m²/g, and the total pore volume is 0.2135 ± 0.0004cm³/g. The degradation ratio of the film electrode with Zn-doped in methyl orange solution is up to 94%. When the react circles is 10 times, the degradation ratio is up to more than 85% and remains steady. With the different reaction conditions, these kinetics of the reactions show some different formulas.

A kinetic equation for photocatalytic activity is established.

Production of waste has been increased exponentially due to world industrialization and urban and machine life expansion. On the other hand, the outbreak of the COVID-19 coronavirus quickly became a global crisis. This crisis has added a large amount of waste to urban waste. The purpose of this study is to create cooperation between municipal waste collector contractors.

Thus, a mathematical model is proposed under uncertain conditions, which includes the volume of municipal waste and infectious waste including personal protective equipment and used equipment for patients. To reduce total costs, the results are evaluated with four cooperative game theory methods such as Shapley value, t value, core center and least core. Ultimately, the saved cost by cooperation in each coalition is allocated fairly among the contractors. Finally, a comparison was made between the solution methods based on the value of the objective function and the solution time.

The results indicate that the proposed cooperative method increases cost savings and reduces the fine of residual waste. Therefore, it can be mentioned that this kind of cooperation would finally result in more incentives for contractors to form larger coalitions. Genetic algorithms were used to solve the large-scale model.

The proposed model boosts the current understanding of waste management in the COVID-19 pandemic. The paper adds additional value by unveiling some key future research directions. This guidance may demonstrate possible existing and unexplored gaps so that researchers can direct future research to develop new processes.