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Lao PDR is a developing country with increasing female participation in the informal labour market. However, these informal female workers are often emotionally and physically drained due to stress in the workplace. This study aims to examine the determinants of job stress on physical symptoms associated with the mental health stigma of informal female workers in Lao PDR.

A convergent parallel approach was used with 1,037 structured interviews and 15 in-depth interviews between October 2017 and June 2019. Fractional response regression was used to analyse the quantitative data and thematic analysis to analyse the qualitative data.

The quantitative data showed a positive effect on job stress and physical symptoms associated with mental health stigma. The qualitative data illustrated that job characteristics, work environment, time pressure, job control, complexity related to workload, physical working conditions and physical demand were associated with emotional distress, depressive symptoms and long-term self-stigma.

The study findings provide guidance for developing strategies for female workers in an informal economy to help mitigate the impacts of job stress related to physical symptoms and mental health stigma.

This study offers a deeper understanding of the emotional and physical stress experienced by informal female workers in the workplace in Lao PDR, showing that job stress due to the physical workload leads to mental health stigma.