Clozapine-induced liver injury and pleural effusion

Joseph P.M. Kane, Francis A. O'Neill

Mental Illness

ISSN: 2036-7465

Open Access. Article publication date: 2 September 2014

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Abstract

Clozapine, whilst associated commonly with a transient and benign increase in liver enzymes, has also been associated with varying presentations of hepatitis in existing case reports. This report describes what we believe to be the first documented case of acute liver injury and pleural effusion associated with clozapine, resolving after cessation of the agent. The case supports existing literature in advocating a high index of suspicion, particularly in the 4-5 weeks following clozapine initiation, when considering nonspecific clinical symptoms and signs.

Keywords

Citation

Kane, J.P.M. and O'Neill, F.A. (2014), "Clozapine-induced liver injury and pleural effusion", Mental Illness, Vol. 6 No. 2, pp. 36-37. https://doi.org/10.1108/mi.2014.5403

Publisher

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Emerald Publishing Limited

Copyright © 2014 J.P.M. Kane and F.A. O'Neill

License

This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0).


Corresponding author

Joseph P.M. Kane, Centre for Public Health, Institute of Clinical Sciences, Queens University Belfast Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, UK. Tel.: +44.289.063.2580.

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