Pharmacological therapies for stroke prevention on major gastrointestinal bleeding in patients with atrial fibrillation

Citation

(2012), "Pharmacological therapies for stroke prevention on major gastrointestinal bleeding in patients with atrial fibrillation", Clinical Governance: An International Journal, Vol. 17 No. 4. https://doi.org/10.1108/cgij.2012.24817daa.005

Pharmacological therapies for stroke prevention on major gastrointestinal bleeding in patients with atrial fibrillation

Pharmacological therapies for stroke prevention on major gastrointestinal bleeding in patients with atrial fibrillation

Article Type: Reviews of effectiveness From: Clinical Governance: An International Journal, Volume 17, Issue 4

Coleman, C.I., Sobieraj, D.M., Winkler, S., Cutting, P., Mediouni, M., Alikhanov, S., Kluger, J.Effect of pharmacological therapies for stroke prevention on major gastrointestinal bleeding in patients with atrial fibrillation,International Journal of Clinical Practice2012Vol. 66 No. 1pp. 53-63

This well-conducted review found that adjusted-dose vitamin K antagonists increased the risk of major gastrointestinal bleeding compared with placebo or aspirin when used for stroke prevention in atrial fibrillation patients; combining vitamin K antagonists with aspirin also increased this risk. The authors’ findings are generally reliable but limited by the small number of trials and rarity of events.