Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials

Citation

(2010), "Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials", Clinical Governance: An International Journal, Vol. 15 No. 2. https://doi.org/10.1108/cgij.2010.24815bae.006

Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials

Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials

Article Type: Reviews of effectiveness From: Clinical Governance: An International Journal, Volume 15, Issue 2

J.C. Nelson, G.I. Papakostas,American Journal of Psychiatry,2009,Vol. 166,pp. 980-91

This review concluded that atypical antipsychotics were effective augmentation agents in major depressive disorder, but were associated with an increased risk of discontinuation due to adverse events. Given some shortcomings in the review process, small sample sizes of a number of trials and the uncertain quality of the included trials, the authors’ conclusions should be interpreted with caution.