In vitro degradation behavior, cytocompatibility and hemocompatibility of topologically ordered functionally graded iron-hydroxyapatite-zinc composite biodegradable biomaterial fabricated using 3D printing and pressureless microwave sintering

Abstract

Purpose

Topologically ordered functionally graded composite (TOFGC) biodegradable materials are needed in the field of metallic degradable implants, as they degrade over a period of time avoiding the necessity of another surgery for implant removal. Also, their rate of degradation can be tailored to match the requirement of the patient. These biomaterials also have the functionality to assist bone growth and eliminate stress shielding in orthopaedic implants.

Design/methodology/approach

In this study, TOFGC biomaterials were developed for the first time using additive manufacturing, pressureless microwave sintering and casting methods, and their cytocompatibility, hemocompatibility and in vitro degradation evaluations were done. Also, pure dense iron and iron scaffolds were included in the study, for the comparison of results with the iron-hydroxyapatite-zinc functionally graded composite biomaterial.

Findings

The maximum weight loss and corrosion rate were found to be 6.98% and 2.38 mmpy, respectively, in the immersion test and electrochemical test for Fe-3.5HAp-54Zn biomaterial. Zinc-infiltrated composite biomaterials exhibited excellent cytocompatibility and hemocompatibility as compared to pure dense iron and iron scaffolds. A comparative analysis was conducted, taking into account relevant literature, and it was determined that the fabricated iron-hydroxyapatite-zinc biomaterial demonstrated desirable degradation and biological characteristics, customized to meet the specific requirements of bone tissue engineering applications.

Originality/value

TOFGC iron-hydroxyapatite-zinc biomaterial has been fabricated for the first time using the developed novel methodology and their degradation and biological characterizations were performed.

Citation

Tripathi, G. and Pandey, P.M. (2024), "In vitro degradation behavior, cytocompatibility and hemocompatibility of topologically ordered functionally graded iron-hydroxyapatite-zinc composite biodegradable biomaterial fabricated using 3D printing and pressureless microwave sintering", Rapid Prototyping Journal, Vol. ahead-of-print No. ahead-of-print. https://doi.org/10.1108/RPJ-07-2024-0286